Gene name
TGFBR1 (ALK5,SKR4)
Experiment(s)
For this entry:
TGFR1_HUMAN (TGFBR1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Yin X,Kang JH,Andrianifahanana M,Wang Y,Jung MY,Hernandez DM,Leof EB (2017) Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif., Mol Biol Cell, 28, 2701-2711. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | The motif identifed as critical for targeting appears to be part of a monoleucine motif NEEDPSLD |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 24 | Signal peptide |
| 25 | 134 | Extracellular |
| 135 | 150 | Membrane |
| 151 | 503 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
| Start | End | Localisation | Type | PubMed |
|---|---|---|---|---|
| 161 | 167 | Basolateral plasma membrane | Monoleucine |
Yin X,Kang JH,Andrianifahanana M,Wang Y,Jung MY,Hernandez DM,Leof EB (2017) Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif., Mol Biol Cell, 28, 2701-2711. [PubMed][DOI] |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 45 | N-GlycoSiteAtlas | 26571101 | |
| 96 | O-GlycoProteomDB |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Activin_recp |
| InterPro | GS_dom |
| InterPro | Kinase-like_dom_sf |
| InterPro | Prot_kinase_dom |
| InterPro | Protein_kinase_ATP_BS |
| InterPro | Ser/Thr_kinase_AS |
| InterPro | TGFB_receptor |
| Pfam | Activin_recp |
| Pfam | Pkinase |
| Pfam | TGF_beta_GS |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| 1433Z_HUMAN | 4 | 19732720 |
| FKB1A_HUMAN | 2 | 24658140 , 10025408 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.