PolarProtDb

Gene name

SLCO4C1 (OATP4C1,SLC21A20,OATPX)

Experiment(s)

For this entry:

SO4C1_HUMAN (SLCO4C1)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Toyohara T,Suzuki T,Morimoto R,Akiyama Y,Souma T,Shiwaku HO,Takeuchi Y,Mishima E,Abe M,Tanemoto M,Masuda S,Kawano H,Maemura K,Nakayama M,Sato H,Mikkaichi T,Yamaguchi H,Fukui S,Fukumoto Y,Shimokawa H,Inui K,Terasaki T,Goto J,Ito S,Hishinuma T,Rubera I,Tauc M,Fujii-Kuriyama Y,Yabuuchi H,Moriyama Y,Soga T,Abe T (2009) SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation., J Am Soc Nephrol, 20, 2546-55. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Kidney
Cell	Proximal tubules
Notes	In the transgenic rat harboring human SLCO4C1

For ortholog entries:

SO4C1_RAT

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	105	Cytoplasmic
106	126	Membrane
127	142	Extracellular
143	165	Membrane
166	173	Cytoplasmic
174	195	Membrane
196	228	Extracellular
229	250	Membrane
251	266	Cytoplasmic
267	289	Membrane
290	312	Extracellular
313	334	Membrane
335	381	Cytoplasmic
382	403	Membrane
404	419	Extracellular
420	443	Membrane
444	455	Cytoplasmic
456	474	Membrane
475	578	Extracellular
579	602	Membrane
603	614	Cytoplasmic
615	638	Membrane
639	666	Extracellular
667	690	Membrane
691	724	Cytoplasmic

Phosphorylation

Position	Resource
15	13310267
16	11537745
24	17546173
28	17546179
79	13310273
81	13310270
141	23146211
203	23146214
208	23146217
460	36276256
461	36276259
473	36276262
543	5678765

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
127	N-GlycoSiteAtlas
544	N-GlycoSiteAtlas		24495048
555	O-GlycoProteomDB
556	O-GlycoProteomDB
557	PhosphoSitePlus
557	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
557	dbPTM		55825681
557	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Kazal_dom
InterPro	Kazal_dom_sf
InterPro	MFS_dom
InterPro	MFS_trans_sf
InterPro	OATP
Pfam	Kazal_2
Pfam	OATP