Gene name
SLCO3A1 (OATP3A1,OATPD,SLC21A11)
Experiment(s)
For this entry:
SO3A1_HUMAN (SLCO3A1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Huber RD,Gao B,Sidler Pfändler MA,Zhang-Fu W,Leuthold S,Hagenbuch B,Folkers G,Meier PJ,Stieger B (2007) Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain., Am J Physiol Cell Physiol, 292, C795-806. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Choroid plexus |
| Cell | Ependymal cells |
| Notes | Splice variant 2 is apically enriched as well as intracellular (last 45 amino acids carry the basolateral signal) |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 40 | Cytoplasmic |
| 41 | 62 | Membrane |
| 63 | 78 | Extracellular |
| 79 | 100 | Membrane |
| 101 | 107 | Cytoplasmic |
| 108 | 129 | Membrane |
| 130 | 177 | Extracellular |
| 178 | 199 | Membrane |
| 200 | 212 | Cytoplasmic |
| 213 | 235 | Membrane |
| 236 | 261 | Extracellular |
| 262 | 284 | Membrane |
| 285 | 349 | Cytoplasmic |
| 350 | 372 | Membrane |
| 373 | 388 | Extracellular |
| 389 | 410 | Membrane |
| 411 | 419 | Cytoplasmic |
| 420 | 441 | Membrane |
| 442 | 538 | Extracellular |
| 539 | 561 | Membrane |
| 562 | 574 | Cytoplasmic |
| 575 | 597 | Membrane |
| 598 | 624 | Extracellular |
| 625 | 647 | Membrane |
| 648 | 710 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 153 | N-GlycoSiteAtlas | 24190977 | |
| 153 | PolarProtDb | 31844046 | |
| 519 | N-GlycoSiteAtlas | 26571101 | |
| 519 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Kazal_dom |
| InterPro | Kazal_dom_sf |
| InterPro | MFS_trans_sf |
| InterPro | OATP |
| Pfam | Kazal_2 |
| Pfam | OATP |