Gene name
SLCO2B1 (KIAA0880,OATP2B1,OATPB,SLC21A9)
Experiment(s)
For this entry:
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Kullak-Ublick GA,Ismair MG,Stieger B,Landmann L,Huber R,Pizzagalli F,Fattinger K,Meier PJ,Hagenbuch B (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver., Gastroenterology, 120, 525-33. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes | Antibody was raised against a C-terminal epitope that could be present in various isoforms |
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
St-Pierre MV,Hagenbuch B,Ugele B,Meier PJ,Stallmach T (2002) Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta., J Clin Endocrinol Metab, 87, 1856-63. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes | "Highly expressed in syncytiotrophoblast cells |
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Kobayashi D,Nozawa T,Imai K,Nezu J,Tsuji A,Tamai I (2003) Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane., J Pharmacol Exp Ther, 306, 703-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT (2005) ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier., Cancer Res, 65, 11419-28. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Sai Y,Kaneko Y,Ito S,Mitsuoka K,Kato Y,Tamai I,Artursson P,Tsuji A (2006) Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells., Drug Metab Dispos, 34, 1423-31. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes |
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Keiser M,Kaltheuner L,Wildberg C,Müller J,Grube M,Partecke LI,Heidecke CD,Oswald S (2017) The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers., J Pharm Sci, 106, 2657-2663. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes | Membranes were analyzed by targeted mass spectrometry instead of western blotting |
SO2B1_HUMAN (SLCO2B1)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Keiser M,Kaltheuner L,Wildberg C,Müller J,Grube M,Partecke LI,Heidecke CD,Oswald S (2017) The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers., J Pharm Sci, 106, 2657-2663. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | CACO-2 cells (enterocytes) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 49 | Cytoplasmic |
| 50 | 69 | Membrane |
| 70 | 87 | Extracellular |
| 88 | 109 | Membrane |
| 110 | 116 | Cytoplasmic |
| 117 | 138 | Membrane |
| 139 | 188 | Extracellular |
| 189 | 211 | Membrane |
| 212 | 224 | Cytoplasmic |
| 225 | 247 | Membrane |
| 248 | 274 | Extracellular |
| 275 | 296 | Membrane |
| 297 | 371 | Cytoplasmic |
| 372 | 393 | Membrane |
| 394 | 409 | Extracellular |
| 410 | 431 | Membrane |
| 432 | 441 | Cytoplasmic |
| 442 | 463 | Membrane |
| 464 | 563 | Extracellular |
| 564 | 587 | Membrane |
| 588 | 600 | Cytoplasmic |
| 601 | 622 | Membrane |
| 623 | 651 | Extracellular |
| 652 | 673 | Membrane |
| 674 | 709 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 176 | N-GlycoSiteAtlas | ||
| 176 | UniPep |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Kazal_dom |
| InterPro | MFS_trans_sf |
| InterPro | OATP |
| Pfam | OATP |