Gene name
SLCO1A2 (OATP,OATP1,OATP1A2,SLC21A3)
Experiment(s)
For this entry:
SO1A2_HUMAN (SLCO1A2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Lee W,Glaeser H,Smith LH,Roberts RL,Moeckel GW,Gervasini G,Leake BF,Kim RB (2005) Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry., J Biol Chem, 280, 9610-7. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
SO1A2_HUMAN (SLCO1A2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Lee W,Glaeser H,Smith LH,Roberts RL,Moeckel GW,Gervasini G,Leake BF,Kim RB (2005) Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry., J Biol Chem, 280, 9610-7. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Bile duct cells |
| Notes |
SO1A2_HUMAN (SLCO1A2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT (2005) ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier., Cancer Res, 65, 11419-28. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
SO1A2_HUMAN (SLCO1A2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Glaeser H,Bailey DG,Dresser GK,Gregor JC,Schwarz UI,McGrath JS,Jolicoeur E,Lee W,Leake BF,Tirona RG,Kim RB (2007) Intestinal drug transporter expression and the impact of grapefruit juice in humans., Clin Pharmacol Ther, 81, 362-70. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
SO1A2_HUMAN (SLCO1A2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Wang H,Yan Z,Dong M,Zhu X,Wang H,Wang Z (2012) Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy., Arch Gynecol Obstet, 285, 1535-40. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Cytoplasmic |
| 21 | 41 | Membrane |
| 42 | 57 | Extracellular |
| 58 | 79 | Membrane |
| 80 | 87 | Cytoplasmic |
| 88 | 109 | Membrane |
| 110 | 158 | Extracellular |
| 159 | 180 | Membrane |
| 181 | 193 | Cytoplasmic |
| 194 | 215 | Membrane |
| 216 | 242 | Extracellular |
| 243 | 265 | Membrane |
| 266 | 316 | Cytoplasmic |
| 317 | 338 | Membrane |
| 339 | 354 | Extracellular |
| 355 | 376 | Membrane |
| 377 | 386 | Cytoplasmic |
| 387 | 408 | Membrane |
| 409 | 513 | Extracellular |
| 514 | 536 | Membrane |
| 537 | 547 | Cytoplasmic |
| 548 | 570 | Membrane |
| 571 | 601 | Extracellular |
| 602 | 623 | Membrane |
| 624 | 670 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 124 | N-GlycoSiteAtlas |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Kazal_dom |
| InterPro | Kazal_dom_sf |
| InterPro | MFS_dom |
| InterPro | MFS_trans_sf |
| InterPro | OATP |
| Pfam | Kazal_2 |
| Pfam | OATP |