Gene name
SCNN1A (SCNN1,Renac)
Experiment(s)
For this entry:
SCNNA_MOUSE (SCNN1A)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Rubera I,Loffing J,Palmer LG,Frindt G,Fowler-Jaeger N,Sauter D,Carroll T,McMahon A,Hummler E,Rossier BC (2003) Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance., J Clin Invest, 112, 554-65. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 109 | Cytoplasmic |
| 110 | 130 | Membrane |
| 131 | 588 | Extracellular |
| 589 | 609 | Membrane |
| 610 | 699 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ENaC |
| InterPro | ENaC_chordates |
| InterPro | ENaC_CS |
| Pfam | ASC |