PolarProtDb

Gene name

SCN2B (Gm183)

Experiment(s)

For this entry:

SCN2B_HUMAN (SCN2B)

Species	Homo sapiens
Localization	Apical plasma membrane
Reference	Cortada E,Brugada R,Verges M (2019) <i>N</i>-Glycosylation of the voltage-gated sodium channel β2 subunit is required for efficient trafficking of Na<sub>V</sub>1.5/β2 to the plasma membrane., J Biol Chem, 294, 16123-16140. [PubMed] [DOI]
Evidence level	Fluorescent tagging
Organ	Kidney
Cell	MDCK cells (distal tubule)
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	30	Signal peptide
31	157	Extracellular
158	179	Membrane
180	215	Cytoplasmic

Phosphorylation

Position	Resource
156	34368799
157	34368802
165	34368805
192	3147477
204	23142100

Glycosylation

Position	Site resource	PubMed link(s)
42	N-GlycoSiteAtlas
42	PolarProtDb	31844046
66	PDB	30765606
66	PDB	30765606
66	PDB	30765606
66	PDB	30765606
66	UniPep
66	UniProtKB	30765606
74	UniPep

Family and domain data

Database	Domain/Family name
InterPro	Ig-like_dom
InterPro	Ig-like_dom_sf
InterPro	Ig-like_fold
InterPro	Ig_sub
InterPro	Ig_V-set
InterPro	Myelin_P0-rel
InterPro	SCN2B
Pfam	V-set