Gene name
Kitlg (Kitl,Mgf,Sl,Slf,SCF)
Experiment(s)
For this entry:
SCF_HUMAN (Kitlg)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Wehrle-Haller B,Imhof BA (2001) Stem cell factor presentation to c-Kit. Identification of a basolateral targeting domain., J Biol Chem, 276, 12667-74. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | A monoleucine motif (NEISMLQ) was identifed as critical for basolateral sorting |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 25 | Signal peptide |
| 26 | 214 | Extracellular |
| 215 | 236 | Membrane |
| 237 | 273 | Cytoplasmic |
Motifs gathered by PolarProtDb Team
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 90 | UniProtKB | 1381905 | |
| 90 | N-GlycoSiteAtlas | ||
| 90 | dbPTM | 1381905 | |
| 97 | N-GlycoSiteAtlas | ||
| 118 | PolarProtDb | 31844046 | |
| 118 | UniProtKB | 1381905 | |
| 118 | dbPTM | 1381905 | |
| 145 | UniProtKB | 1381905 | |
| 145 | dbPTM | 1381905 | |
| 160 | O-GlycoProteomDB | ||
| 166 | O-GlycoProteomDB | ||
| 167 | O-GlycoProteomDB | ||
| 167 | UniProtKB | 1381905 | |
| 168 | O-GlycoProteomDB | ||
| 168 | UniProtKB | 1381905 | |
| 170 | O-GlycoProteomDB | ||
| 178 | O-GlycoProteomDB | ||
| 180 | O-GlycoProteomDB | ||
| 180 | UniProtKB | 1381905 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | 4_helix_cytokine-like_core |
| InterPro | SCF |
| Pfam | SCF |