Gene name
SLC5A12 (SMCT2)
Experiment(s)
For this entry:
SC5AC_MOUSE (SLC5A12)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Gopal E,Umapathy NS,Martin PM,Ananth S,Gnana-Prakasam JP,Becker H,Wagner CA,Ganapathy V,Prasad PD (2007) Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney., Biochim Biophys Acta, 1768, 2690-7. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 10 | Extracellular |
| 11 | 30 | Membrane |
| 31 | 49 | Cytoplasmic |
| 50 | 70 | Membrane |
| 71 | 81 | Extracellular |
| 82 | 103 | Membrane |
| 104 | 124 | Cytoplasmic |
| 125 | 146 | Membrane |
| 147 | 155 | Extracellular |
| 156 | 176 | Membrane |
| 177 | 185 | Cytoplasmic |
| 186 | 206 | Membrane |
| 207 | 236 | Extracellular |
| 237 | 255 | Membrane |
| 256 | 275 | Cytoplasmic |
| 276 | 297 | Membrane |
| 298 | 331 | Extracellular |
| 332 | 353 | Membrane |
| 354 | 382 | Cytoplasmic |
| 383 | 402 | Membrane |
| 403 | 409 | Extracellular |
| 410 | 430 | Membrane |
| 431 | 437 | Cytoplasmic |
| 438 | 458 | Membrane |
| 459 | 504 | Extracellular |
| 505 | 525 | Membrane |
| 526 | 619 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/Glc_symporter_sf |
| InterPro | Na/solute_symporter |
| InterPro | SMCT2_SLC5sbd |
| Pfam | SSF |