Gene name
SLC5A5 (NIS)
Experiment(s)
For this entry:
SC5A5_HUMAN (SLC5A5)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Filetti S,Bidart JM,Arturi F,Caillou B,Russo D,Schlumberger M (1999) Sodium/iodide symporter: a key transport system in thyroid cancer cell metabolism., Eur J Endocrinol, 141, 443-57. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Thyroid gland |
| Cell | Follicular cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 13 | Extracellular |
| 14 | 34 | Membrane |
| 35 | 54 | Cytoplasmic |
| 55 | 76 | Membrane |
| 77 | 87 | Extracellular |
| 88 | 109 | Membrane |
| 110 | 130 | Cytoplasmic |
| 131 | 151 | Membrane |
| 152 | 163 | Extracellular |
| 164 | 184 | Membrane |
| 185 | 191 | Cytoplasmic |
| 192 | 212 | Membrane |
| 213 | 241 | Extracellular |
| 242 | 261 | Membrane |
| 262 | 281 | Cytoplasmic |
| 282 | 303 | Membrane |
| 304 | 340 | Extracellular |
| 341 | 362 | Membrane |
| 363 | 383 | Cytoplasmic |
| 384 | 405 | Membrane |
| 406 | 415 | Extracellular |
| 416 | 437 | Membrane |
| 438 | 443 | Cytoplasmic |
| 444 | 465 | Membrane |
| 466 | 527 | Extracellular |
| 528 | 549 | Membrane |
| 550 | 643 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/Glc_symporter_sf |
| InterPro | Na/solute_symporter |
| InterPro | Na/solute_symporter_CS |
| InterPro | SLC5A5 |
| Pfam | SSF |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CRTP1_HUMAN | 3 | 32296183 |
| NT2NC_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.