Gene name
SLC6A20 (SIT1,XT3,XTRP3)
Experiment(s)
For this entry:
S6A20_HUMAN (SLC6A20)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bröer S,Bailey CG,Kowalczuk S,Ng C,Vanslambrouck JM,Rodgers H,Auray-Blais C,Cavanaugh JA,Bröer A,Rasko JE (2008) Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters., J Clin Invest, 118, 3881-92. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 13 | Cytoplasmic |
| 14 | 31 | Membrane |
| 32 | 43 | Extracellular |
| 44 | 65 | Membrane |
| 66 | 85 | Cytoplasmic |
| 86 | 106 | Membrane |
| 107 | 165 | Extracellular |
| 166 | 186 | Membrane |
| 187 | 195 | Cytoplasmic |
| 196 | 217 | Membrane |
| 218 | 243 | Extracellular |
| 244 | 264 | Membrane |
| 265 | 276 | Cytoplasmic |
| 277 | 298 | Membrane |
| 299 | 390 | Extracellular |
| 391 | 411 | Membrane |
| 412 | 431 | Cytoplasmic |
| 432 | 452 | Membrane |
| 453 | 464 | Extracellular |
| 465 | 486 | Membrane |
| 487 | 506 | Cytoplasmic |
| 507 | 527 | Membrane |
| 528 | 554 | Extracellular |
| 555 | 575 | Membrane |
| 576 | 592 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/ntran_symport |
| InterPro | Neutral_aa_SLC6 |
| InterPro | SNS_sf |
| Pfam | SNF |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| KR108_HUMAN | 6 | 25416956 , 32296183 |
| ATL4_HUMAN | 3 | 25416956 |
| KRA11_HUMAN | 3 | 32296183 |
| NT2NC_HUMAN | 3 | 32296183 |
| KR107_HUMAN | 3 | 25416956 |
| NT2NA_HUMAN | 3 | 25416956 |
| KR105_HUMAN | 3 | 25416956 |
| CRTP1_HUMAN | 3 | 32296183 |
| KR109_HUMAN | 3 | 25416956 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.