Gene name
SLC4A7 (BT,Nbc2,NBC2B,Nbc3,Nbcn1,SBC2,SLC4A6,Nbc)
Experiment(s)
For this entry:
S4A7_HUMAN (SLC4A7)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Damkier HH,Nielsen S,Praetorius J (2007) Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues., Am J Physiol Regul Integr Comp Physiol, 293, R2136-46. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Henle's loop / TAL cells |
| Notes |
S4A7_HUMAN (SLC4A7)
| Species | Homo sapiens |
|---|---|
| Localization | Non polar membrane |
| Reference |
Damkier HH,Nielsen S,Praetorius J (2007) Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues., Am J Physiol Regul Integr Comp Physiol, 293, R2136-46. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 607 | Extracellular |
| 608 | 629 | Membrane |
| 630 | 644 | Cytoplasmic |
| 645 | 664 | Membrane |
| 665 | 693 | Extracellular |
| 694 | 719 | Membrane |
| 720 | 724 | Cytoplasmic |
| 725 | 740 | Membrane |
| 741 | 823 | Extracellular |
| 824 | 842 | Membrane |
| 843 | 858 | Cytoplasmic |
| 859 | 879 | Membrane |
| 880 | 909 | Extracellular |
| 910 | 929 | Membrane |
| 930 | 952 | Cytoplasmic |
| 953 | 972 | Membrane |
| 973 | 1009 | Extracellular |
| 1010 | 1029 | Membrane |
| 1030 | 1035 | Cytoplasmic |
| 1036 | 1055 | Membrane |
| 1056 | 1090 | Extracellular |
| 1091 | 1118 | Membrane |
| 1119 | 1214 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 26 | 23145965 |
| 30 | 25311577 |
| 39 | 27461112 |
| 44 | 464641 |
| 52 | 9764068 |
| 55 | 8096079 |
| 76 | 4251112 |
| 84 | 2509359 |
| 86 | 5750409 |
| 87 | 4251115 |
| 89 | 3887837 |
| 91 | 3685317 |
| 114 | 23145968 |
| 121 | 474349 |
| 127 | 474350 |
| 132 | 23145971 |
| 150 | 36702081 |
| 153 | 15229835 |
| 156 | 23145974 |
| 167 | 3657043 |
| 181 | 3657046 |
| 182 | 3657049 |
| 197 | 3657052 |
| 203 | 3657055 |
| 225 | 15406194 |
| 226 | 12260290 |
| 233 | 4149636 |
| 242 | 4149642 |
| 260 | 3657058 |
| 266 | 3657061 |
| 271 | 25311575 |
| 297 | 3657064 |
| 317 | 3657067 |
| 390 | 31879971 |
| 392 | 41454485 |
| 400 | 3217845 |
| 403 | 468766 |
| 407 | 468767 |
| 408 | 1216901 |
| 412 | 11179187 |
| 429 | 3657070 |
| 459 | 3657073 |
| 481 | 14567516 |
| 487 | 14567519 |
| 490 | 14567525 |
| 493 | 14567522 |
| 556 | 4149648 |
| 557 | 3958099 |
| 559 | 4149654 |
| 563 | 18015873 |
| 663 | 3657076 |
| 867 | 3657079 |
| 1167 | 3217848 |
| 1176 | 3217842 |
| 1188 | 2803402 |
| 1194 | 7755600 |
| 1198 | 31871240 |
| 1207 | 34606358 |
| 1213 | 451988 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 171 | UniPep | ||
| 554 | N-GlycoSiteAtlas | 26571101 | |
| 776 | dbPTM | 19349973 | |
| 776 | N-GlycoSiteAtlas | ||
| 776 | PolarProtDb | 31844046 | |
| 776 | UniPep | ||
| 776 | UniProtKB | 19349973 | |
| 786 | PolarProtDb | 31844046 | |
| 786 | UniProtKB | 19349973 | |
| 786 | UniPep | ||
| 786 | N-GlycoSiteAtlas | 21621025 , 25285165 , 26571101 , 26256267 , 25902405 | |
| 786 | dbPTM | 19349973 | |
| 791 | dbPTM | 19349973 | |
| 791 | N-GlycoSiteAtlas | 21621025 , 25285165 , 26571101 , 26256267 , 25902405 | |
| 791 | PolarProtDb | 31844046 | |
| 791 | UniPep | ||
| 791 | UniProtKB | 19349973 | |
| 796 | N-GlycoSiteAtlas | 24721674 , 26256267 , 25902405 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Band3_cytoplasmic_dom |
| InterPro | HCO3_transpt_C |
| InterPro | HCO3_transpt_euk |
| InterPro | PTrfase/Anion_transptr |
| Pfam | Band_3_cyto |
| Pfam | HCO3_cotransp |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| KRA45_HUMAN | 3 | 32296183 |
| USH1C_HUMAN | 2 | 16301216 |
| CIAO1_HUMAN | 3 | 32296183 |
| TMM17_HUMAN | 2 | 26638075 |
| 1433B_HUMAN | 2 | 28514442 , 17353931 |
| LAMP1_HUMAN | 3 | 29568061 |
| TGON2_HUMAN | 3 | 29568061 |
| TM216_HUMAN | 2 | 26638075 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.