Gene name
SLC4A5 (NBC4)
Experiment(s)
For this entry:
S4A5_HUMAN (SLC4A5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Damkier HH,Nielsen S,Praetorius J (2007) Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues., Am J Physiol Regul Integr Comp Physiol, 293, R2136-46. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 523 | Cytoplasmic |
| 524 | 539 | Membrane |
| 540 | 555 | Extracellular |
| 556 | 571 | Membrane |
| 572 | 573 | Cytoplasmic |
| 574 | 589 | Membrane |
| 590 | 605 | Extracellular |
| 606 | 621 | Membrane |
| 622 | 639 | Cytoplasmic |
| 640 | 657 | Membrane |
| 658 | 745 | Extracellular |
| 746 | 761 | Membrane |
| 762 | 777 | Cytoplasmic |
| 778 | 793 | Membrane |
| 794 | 830 | Extracellular |
| 831 | 851 | Membrane |
| 852 | 872 | Cytoplasmic |
| 873 | 888 | Membrane |
| 889 | 890 | Extracellular |
| 891 | 906 | Membrane |
| 907 | 928 | Cytoplasmic |
| 929 | 944 | Membrane |
| 945 | 952 | Extracellular |
| 953 | 968 | Membrane |
| 969 | 1025 | Cytoplasmic |
| 1026 | 1044 | Re-entrant loop |
| 1045 | 1137 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Band3_cytoplasmic_dom |
| InterPro | HCO3_transpt_C |
| InterPro | HCO3_transpt_euk |
| InterPro | Na/HCO3_transpt |
| InterPro | PTrfase/Anion_transptr |
| Pfam | Band_3_cyto |
| Pfam | HCO3_cotransp |