Gene name
Slc29a4 (ENT4,PMAT)
Experiment(s)
For this entry:
S29A4_HUMAN (Slc29a4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Duan H,Wang J (2013) Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene., J Biol Chem, 288, 3535-44. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Choroid plexus |
| Cell | Ependymal cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 68 | Cytoplasmic |
| 69 | 89 | Membrane |
| 90 | 105 | Extracellular |
| 106 | 126 | Membrane |
| 127 | 135 | Cytoplasmic |
| 136 | 156 | Membrane |
| 157 | 165 | Extracellular |
| 166 | 186 | Membrane |
| 187 | 200 | Cytoplasmic |
| 201 | 221 | Membrane |
| 222 | 231 | Extracellular |
| 232 | 252 | Membrane |
| 253 | 351 | Cytoplasmic |
| 352 | 372 | Membrane |
| 373 | 381 | Extracellular |
| 382 | 402 | Membrane |
| 403 | 415 | Cytoplasmic |
| 416 | 436 | Membrane |
| 437 | 449 | Extracellular |
| 450 | 470 | Membrane |
| 471 | 484 | Cytoplasmic |
| 485 | 505 | Membrane |
| 506 | 530 | Extracellular |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 523 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ENT4 |
| InterPro | Eqnu_transpt |
| InterPro | MFS_trans_sf |
| Pfam | Nucleoside_tran |