Gene name
SLC28A1 (Cnt1)
Experiment(s)
For this entry:
S28A1_RAT (SLC28A1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Mangravite LM,Lipschutz JH,Mostov KE,Giacomini KM (2001) Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line., Am J Physiol Renal Physiol, 280, F879-85. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | LLC-PK1 cells (proximal tubule) |
| Notes |
S28A1_RAT (SLC28A1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Mangravite LM,Lipschutz JH,Mostov KE,Giacomini KM (2001) Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line., Am J Physiol Renal Physiol, 280, F879-85. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Location was also confirmed by a functional transport assay |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 83 | Extracellular |
| 84 | 104 | Membrane |
| 105 | 108 | Cytoplasmic |
| 109 | 128 | Membrane |
| 129 | 149 | Extracellular |
| 150 | 170 | Membrane |
| 171 | 178 | Cytoplasmic |
| 179 | 195 | Membrane |
| 196 | 205 | Extracellular |
| 206 | 224 | Membrane |
| 225 | 260 | Cytoplasmic |
| 261 | 283 | Membrane |
| 284 | 339 | Extracellular |
| 340 | 360 | Membrane |
| 361 | 364 | Cytoplasmic |
| 365 | 385 | Membrane |
| 386 | 423 | Extracellular |
| 424 | 446 | Membrane |
| 447 | 456 | Cytoplasmic |
| 457 | 477 | Membrane |
| 478 | 531 | Extracellular |
| 532 | 554 | Membrane |
| 555 | 568 | Cytoplasmic |
| 569 | 591 | Membrane |
| 592 | 648 | Extracellular |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | C_nuclsd_transpt |
| InterPro | C_nuclsd_transpt_met_bac |
| InterPro | CNT1/CNT2 |
| InterPro | CNT_C_dom |
| InterPro | CNT_N_dom |
| InterPro | Gate_dom |
| Pfam | Gate |
| Pfam | Nucleos_tra2_C |
| Pfam | Nucleos_tra2_N |