Gene name
SLC26A5 (PRES)
Experiment(s)
For this entry:
S26A5_MOUSE (SLC26A5)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Zhang Y,Moeini-Naghani I,Bai J,Santos-Sacchi J,Navaratnam DS (2015) Tyrosine motifs are required for prestin basolateral membrane targeting., Biol Open, 4, 197-205. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Inner ear |
| Cell | Hair cells |
| Notes | Gerbil prestin was also found to localize basolaterally when transfected into MDCK cells |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 83 | Cytoplasmic |
| 84 | 104 | Membrane |
| 105 | 109 | Extracellular |
| 110 | 129 | Membrane |
| 130 | 131 | Cytoplasmic |
| 132 | 152 | Membrane |
| 153 | 175 | Extracellular |
| 176 | 196 | Membrane |
| 197 | 208 | Cytoplasmic |
| 209 | 229 | Membrane |
| 230 | 255 | Extracellular |
| 256 | 275 | Membrane |
| 276 | 287 | Cytoplasmic |
| 288 | 307 | Membrane |
| 308 | 337 | Extracellular |
| 338 | 358 | Membrane |
| 359 | 374 | Cytoplasmic |
| 375 | 395 | Membrane |
| 396 | 411 | Extracellular |
| 412 | 432 | Membrane |
| 433 | 437 | Cytoplasmic |
| 438 | 458 | Membrane |
| 459 | 473 | Extracellular |
| 474 | 501 | Membrane |
| 502 | 744 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Prestin |
| InterPro | S04_transporter_CS |
| InterPro | SLC26A/SulP_dom |
| InterPro | SLC26A/SulP_fam |
| InterPro | STAS_dom |
| InterPro | STAS_dom_sf |
| Pfam | STAS |
| Pfam | Sulfate_transp |