Gene name
Slc26a3 (Dra)
Experiment(s)
For this entry:
S26A3_HUMAN (Slc26a3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Hayashi H,Yamashita Y (2012) Role of N-glycosylation in cell surface expression and protection against proteolysis of the intestinal anion exchanger SLC26A3., Am J Physiol Cell Physiol, 302, C781-95. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | HA tag was used for labelling. N-glylosylation had an effect on proteolytic stability but not apical targeting |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 76 | Cytoplasmic |
| 77 | 97 | Membrane |
| 98 | 102 | Extracellular |
| 103 | 120 | Membrane |
| 121 | 124 | Cytoplasmic |
| 125 | 145 | Membrane |
| 146 | 175 | Extracellular |
| 176 | 196 | Membrane |
| 197 | 208 | Cytoplasmic |
| 209 | 226 | Membrane |
| 227 | 256 | Extracellular |
| 257 | 274 | Membrane |
| 275 | 289 | Cytoplasmic |
| 290 | 307 | Membrane |
| 308 | 337 | Extracellular |
| 338 | 358 | Membrane |
| 359 | 374 | Cytoplasmic |
| 375 | 395 | Membrane |
| 396 | 411 | Extracellular |
| 412 | 432 | Membrane |
| 433 | 437 | Cytoplasmic |
| 438 | 455 | Membrane |
| 456 | 471 | Extracellular |
| 472 | 499 | Membrane |
| 500 | 764 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 153 | dbPTM | 22159084 | |
| 153 | N-GlycoSiteAtlas | 23712678 | |
| 153 | UniProtKB | 22159084 | |
| 161 | dbPTM | 22159084 | |
| 161 | N-GlycoSiteAtlas | 23712678 | |
| 161 | UniProtKB | 22159084 | |
| 164 | N-GlycoSiteAtlas | 23712678 | |
| 165 | dbPTM | 22159084 | |
| 165 | N-GlycoSiteAtlas | 23712678 | |
| 165 | UniProtKB | 22159084 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | S04_transporter_CS |
| InterPro | SLC26A/SulP_dom |
| InterPro | SLC26A/SulP_fam |
| InterPro | SLC26A3 |
| InterPro | STAS_dom |
| InterPro | STAS_dom_sf |
| Pfam | STAS |
| Pfam | Sulfate_transp |