Gene name

SLC22A11 (OAT4)

Experiment(s)

For this entry:
S22AB_HUMAN (SLC22A11)
Species Homo sapiens
Localization Apical plasma membrane
Reference Ekaratanawong S,Anzai N,Jutabha P,Miyazaki H,Noshiro R,Takeda M,Kanai Y,Sophasan S,Endou H (2004) Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules., J Pharmacol Sci, 94, 297-304.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes
S22AB_HUMAN (SLC22A11)
Species Homo sapiens
Localization Apical plasma membrane
Reference Miyazaki H,Anzai N,Ekaratanawong S,Sakata T,Shin HJ,Jutabha P,Hirata T,He X,Nonoguchi H,Tomita K,Kanai Y,Endou H (2005) Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins., J Am Soc Nephrol, 16, 3498-506.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Kidney
Cell Proximal tubules
Notes Apical localization was modulated by NHERF-family protein binding (through a PDZ motif)
S22AB_HUMAN (SLC22A11)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Ugele B,St-Pierre MV,Pihusch M,Bahn A,Hantschmann P (2003) Characterization and identification of steroid sulfate transporters of human placenta., Am J Physiol Endocrinol Metab, 284, E390-8.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Placenta
Cell Trophoblast cells
Notes
S22AB_HUMAN (SLC22A11)
Species Homo sapiens
Localization Basolateral plasma membrane
Reference Uehara I,Kimura T,Tanigaki S,Fukutomi T,Sakai K,Shinohara Y,Ichida K,Iwashita M,Sakurai H (2014) Paracellular route is the major urate transport pathway across the blood-placental barrier., Physiol Rep, 2, .
[PubMed] [DOI]
Evidence level Antibody staining
Organ Placenta
Cell Trophoblast cells
Notes
For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 18 Cytoplasmic
19 38 Membrane
39 143 Extracellular
144 164 Membrane
165 171 Cytoplasmic
172 191 Membrane
192 198 Extracellular
199 219 Membrane
220 228 Cytoplasmic
229 249 Membrane
250 256 Extracellular
257 276 Membrane
277 344 Cytoplasmic
345 364 Membrane
365 374 Extracellular
375 396 Membrane
397 403 Cytoplasmic
404 423 Membrane
424 430 Extracellular
431 451 Membrane
452 463 Cytoplasmic
464 484 Membrane
485 491 Extracellular
492 512 Membrane
513 550 Cytoplasmic
Motifs gathered by PolarProtDb Team
Start End Localisation Type PubMed
545 550 Apical plasma membrane PDZ-ligand Miyazaki H,Anzai N,Ekaratanawong S,Sakata T,Shin HJ,Jutabha P,Hirata T,He X,Nonoguchi H,Tomita K,Kanai Y,Endou H (2005) Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins., J Am Soc Nephrol, 16, 3498-506.
[PubMed][DOI]
Phosphorylation
Position Resource
65 23145163

Family and domain data

Database Domain/Family name
InterPro MFS_dom
InterPro MFS_sugar_transport-like
InterPro MFS_trans_sf
Pfam Sugar_tr

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