Gene name
SLC22A8 (OAT3,Roct)
Experiment(s)
For this entry:
S22A8_MOUSE (SLC22A8)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Breljak D,Brzica H,Sweet DH,Anzai N,Sabolic I (2013) Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys., Am J Physiol Renal Physiol, 304, F1114-26. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 17 | Cytoplasmic |
| 18 | 37 | Membrane |
| 38 | 123 | Extracellular |
| 124 | 143 | Membrane |
| 144 | 150 | Cytoplasmic |
| 151 | 170 | Membrane |
| 171 | 177 | Extracellular |
| 178 | 198 | Membrane |
| 199 | 208 | Cytoplasmic |
| 209 | 229 | Membrane |
| 230 | 236 | Extracellular |
| 237 | 256 | Membrane |
| 257 | 325 | Cytoplasmic |
| 326 | 346 | Membrane |
| 347 | 356 | Extracellular |
| 357 | 377 | Membrane |
| 378 | 384 | Cytoplasmic |
| 385 | 404 | Membrane |
| 405 | 412 | Extracellular |
| 413 | 433 | Membrane |
| 434 | 443 | Cytoplasmic |
| 444 | 465 | Membrane |
| 466 | 471 | Extracellular |
| 472 | 492 | Membrane |
| 493 | 537 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 293 | 1868283059 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| Pfam | Sugar_tr |