Gene name
SLC22A3 (Oct3,EMTH)
Experiment(s)
For this entry:
S22A3_HUMAN (SLC22A3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Müller J,Lips KS,Metzner L,Neubert RH,Koepsell H,Brandsch M (2005) Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)., Biochem Pharmacol, 70, 1851-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes |
S22A3_HUMAN (SLC22A3)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Nies AT,Koepsell H,Winter S,Burk O,Klein K,Kerb R,Zanger UM,Keppler D,Schwab M,Schaeffeler E (2009) Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver., Hepatology, 50, 1227-40. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Cytoplasmic |
| 21 | 41 | Membrane |
| 42 | 155 | Extracellular |
| 156 | 175 | Membrane |
| 176 | 182 | Cytoplasmic |
| 183 | 202 | Membrane |
| 203 | 209 | Extracellular |
| 210 | 230 | Membrane |
| 231 | 240 | Cytoplasmic |
| 241 | 261 | Membrane |
| 262 | 268 | Extracellular |
| 269 | 288 | Membrane |
| 289 | 350 | Cytoplasmic |
| 351 | 370 | Membrane |
| 371 | 380 | Extracellular |
| 381 | 401 | Membrane |
| 402 | 407 | Cytoplasmic |
| 408 | 428 | Membrane |
| 429 | 435 | Extracellular |
| 436 | 457 | Membrane |
| 458 | 467 | Cytoplasmic |
| 468 | 489 | Membrane |
| 490 | 496 | Extracellular |
| 497 | 517 | Membrane |
| 518 | 556 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 72 | N-GlycoSiteAtlas | 24324730 , 24495048 | |
| 72 | PolarProtDb | 31844046 | |
| 99 | N-GlycoSiteAtlas | 24495048 | |
| 119 | N-GlycoSiteAtlas | 24495048 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS |
| InterPro | MFS_dom |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | MFS_1 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ABL1_HUMAN | 2 | 17474147 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.