Gene name
SLC22A2 (OCT2)
Experiment(s)
For this entry:
S22A2_RAT (SLC22A2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Karbach U,Kricke J,Meyer-Wentrup F,Gorboulev V,Volk C,Loffing-Cueni D,Kaissling B,Bachmann S,Koepsell H (2000) Localization of organic cation transporters OCT1 and OCT2 in rat kidney., Am J Physiol Renal Physiol, 279, F679-87. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Cytoplasmic |
| 21 | 41 | Membrane |
| 42 | 150 | Extracellular |
| 151 | 170 | Membrane |
| 171 | 177 | Cytoplasmic |
| 178 | 198 | Membrane |
| 199 | 205 | Extracellular |
| 206 | 226 | Membrane |
| 227 | 236 | Cytoplasmic |
| 237 | 256 | Membrane |
| 257 | 263 | Extracellular |
| 264 | 283 | Membrane |
| 284 | 347 | Cytoplasmic |
| 348 | 367 | Membrane |
| 368 | 377 | Extracellular |
| 378 | 398 | Membrane |
| 399 | 404 | Cytoplasmic |
| 405 | 425 | Membrane |
| 426 | 432 | Extracellular |
| 433 | 453 | Membrane |
| 454 | 464 | Cytoplasmic |
| 465 | 485 | Membrane |
| 486 | 492 | Extracellular |
| 493 | 514 | Membrane |
| 515 | 555 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 334 | 17544827 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS_dom |
| InterPro | MFS_sugar_transport-like |
| InterPro | MFS_trans_sf |
| InterPro | Orgcat_transp/SVOP |
| InterPro | Sugar_transporter_CS |
| Pfam | Sugar_tr |