Gene name
Slc12a7 (Kcc4)
Experiment(s)
For this entry:
S12A7_RAT (Slc12a7)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Melo Z,Cruz-Rangel S,Bautista R,Vázquez N,Castañeda-Bueno M,Mount DB,Pasantes-Morales H,Mercado A,Gamba G (2013) Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney., Am J Physiol Renal Physiol, 305, F1402-11. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Alpha intercalated cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 118 | Cytoplasmic |
| 119 | 139 | Membrane |
| 140 | 153 | Extracellular |
| 154 | 176 | Membrane |
| 177 | 196 | Cytoplasmic |
| 197 | 220 | Membrane |
| 221 | 250 | Extracellular |
| 251 | 270 | Membrane |
| 271 | 275 | Cytoplasmic |
| 276 | 296 | Membrane |
| 297 | 415 | Extracellular |
| 416 | 436 | Membrane |
| 437 | 455 | Cytoplasmic |
| 456 | 477 | Membrane |
| 478 | 498 | Extracellular |
| 499 | 520 | Membrane |
| 521 | 556 | Cytoplasmic |
| 557 | 574 | Membrane |
| 575 | 579 | Extracellular |
| 580 | 600 | Membrane |
| 601 | 616 | Cytoplasmic |
| 617 | 634 | Membrane |
| 635 | 636 | Extracellular |
| 637 | 654 | Membrane |
| 655 | 849 | Cytoplasmic |
| 850 | 865 | Membrane |
| 866 | 1083 | Extracellular |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 108 | 111 | SRRR | TRG_ER_diArg_1 |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AA-permease/SLC12A_dom |
| InterPro | KCC4 |
| InterPro | KCL_cotranspt |
| InterPro | SLC12_C |
| InterPro | SLC12A_fam |
| Pfam | AA_permease |
| Pfam | SLC12 |