Gene name
AGER (Rage)
Experiment(s)
For this entry:
RAGE_HUMAN (AGER)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Shirasawa M,Fujiwara N,Hirabayashi S,Ohno H,Iida J,Makita K,Hata Y (2004) Receptor for advanced glycation end-products is a marker of type I lung alveolar cells., Genes Cells, 9, 165-74. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
RAGE_HUMAN (AGER)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Zen K,Chen CX,Chen YT,Wilton R,Liu Y (2007) Receptor for advanced glycation endproducts mediates neutrophil migration across intestinal epithelium., J Immunol, 178, 2483-90. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Large intestine |
| Cell | T84 cells (enterocytes) |
| Notes | Detecting endogenous proteins |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 22 | Signal peptide |
| 23 | 340 | Extracellular |
| 341 | 361 | Membrane |
| 362 | 404 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | CD80_C2-set |
| InterPro | Ig-like_dom |
| InterPro | Ig-like_dom_sf |
| InterPro | Ig-like_fold |
| InterPro | Ig/MHC_CS |
| InterPro | Ig_sub |
| InterPro | Ig_sub2 |
| InterPro | Immunoglobulin |
| Pfam | C2-set_2 |
| Pfam | ig |
| Pfam | Ig_2 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CKLF7_HUMAN | 3 | 32296183 |
| NCK1_HUMAN | 2 | 17474147 |
| IRAK4_HUMAN | 4 | 21829704 |
| GRB2_HUMAN | 2 | 17474147 , 21706016 |
| MYD88_HUMAN | 8 | 21829704 |
| TIRAP_HUMAN | 9 | 21829704 |
| CREB3_HUMAN | 3 | 25910212 |
| S100P_HUMAN | 2 | 16061848 |
| KPCZ_HUMAN | 6 | 21829704 |
| TTMP_HUMAN | 3 | 32296183 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.