Gene name
PTPRH (SAP-1,SAP1)
Experiment(s)
For this entry:
PTPRH_MOUSE (PTPRH)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Sadakata H,Okazawa H,Sato T,Supriatna Y,Ohnishi H,Kusakari S,Murata Y,Ito T,Nishiyama U,Minegishi T,Harada A,Matozaki T (2009) SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis., Genes Cells, 14, 295-308. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Small intestine |
| Cell | Enterocytes |
| Notes | Goblet cells do not express this protein |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 28 | Signal peptide |
| 29 | 610 | Extracellular |
| 611 | 626 | Membrane |
| 627 | 971 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | FN3_dom |
| InterPro | FN3_sf |
| InterPro | Ig-like_fold |
| InterPro | Prot-tyrosine_phosphatase-like |
| InterPro | PTPase_domain |
| InterPro | R-PTP-H |
| InterPro | Tyr_Pase_AS |
| InterPro | Tyr_Pase_cat |
| InterPro | TYR_PHOSPHATASE_dom |
| Pfam | fn3 |
| Pfam | Y_phosphatase |