PolarProtDb

Gene name

ALPL (Akp-2,Akp2)

Experiment(s)

For this entry:

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	524	Extracellular

Phosphorylation

Position	Resource
68	27620904
110	4702206

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
140	PolarProtDb		31844046
140	UniProtKB		19349973
140	dbPTM		19349973
230	Glyconnect	$WURCS=2.0/3,6,5/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-2-3-3-3/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30899004
230	dbPTM		19349973
230	PolarProtDb		31844046
230	UniProtKB		19349973
271	Glyconnect	$WURCS=2.0/2,7,6/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?_a?\|b?\|c?\|d?\|e?\|f?\|g?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?$	30899004
303	dbPTM		19349973
303	UniProtKB		19349973
430	ACGGD-BD
430	UniProtKB		19349973
430	PolarProtDb		31844046
430	dbPTM		19349973
430	ACGGD-BD
430	ACGGD-BD
430	ACGGD-BD
430	ACGGD-BD
430	ACGGD-BD
439	dbPTM		19349973

Family and domain data

Database	Domain/Family name
InterPro	Alkaline_phosphatase
InterPro	Alkaline_phosphatase_AS
InterPro	Alkaline_phosphatase_core_sf
Pfam	Alk_phosphatase

Interactions

With (links to EBI)	#Exp	PubMed links
HD_HUMAN	2	17500595

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.