Gene name
PODXL (PCLP,PCLP1)
Experiment(s)
For this entry:
PODXL_HUMAN (PODXL)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Mammary gland |
Cell | MCF10A cells (acinar cells) |
Notes |
PODXL_HUMAN (PODXL)
Species | Homo sapiens |
---|---|
Localization | Apical plasma membrane |
Reference |
Lampugnani MG,Orsenigo F,Rudini N,Maddaluno L,Boulday G,Chapon F,Dejana E (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity., J Cell Sci, 123, 1073-80. [PubMed] [DOI] |
Evidence level | Antibody staining |
Organ | Vessels |
Cell | HUVEC cells (endothelial cells) |
Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 22 | Signal peptide |
23 | 461 | Extracellular |
462 | 483 | Membrane |
484 | 558 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
Start | End | Sequence | Motif |
---|---|---|---|
554 | 558 | EDTHL | TRG_PTS1 |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | CD34/Podocalyxin |
InterPro | PODXL |
Pfam | CD34_antigen |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
IQGA1_HUMAN | 4 | 22662192 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.