PolarProtDb

Gene name

P2RX4 (P2x4)

Experiment(s)

For this entry:

P2RX4_MOUSE (P2RX4)

Species	Mus musculus
Localization	Apical plasma membrane
Reference	Battistone MA,Merkulova M,Park YJ,Peralta MA,Gombar F,Brown D,Breton S (2019) Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine., J Physiol, 597, 1957-1973. [PubMed] [DOI]
Evidence level	Antibody staining
Organ	Epididymis
Cell	Principal cells
Notes

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	33	Cytoplasmic
34	52	Membrane
53	329	Extracellular
330	353	Membrane
354	388	Cytoplasmic

Phosphorylation

Position	Resource
378	14510900

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
75	Glyconnect	$WURCS=2.0/3,6,5/[axxxxm-1x_1-5][axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-2-2-3-3-3/a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?_a?\|b?\|c?\|d?\|e?\|f?}-{a?\|b?\|c?\|d?\|e?\|f?$	30899004
75	PolarProtDb		31844046
208	Glyconnect	$WURCS=2.0/2,11,10/[axxxxh-1x_1-5_2*NCC/3=O][axxxxh-1x_1-5]/1-1-2-2-2-2-2-2-2-2-2/a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?_a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?}-{a?\|b?\|c?\|d?\|e?\|f?\|g?\|h?\|i?\|j?\|k?$	30899004

Family and domain data

Database	Domain/Family name
InterPro	P2X4_purnocptor
InterPro	P2X_extracellular_dom_sf
InterPro	P2X_purnocptor