Gene name
SLC10A1 (Ntcp,Slc10a1)
Experiment(s)
For this entry:
NTCP_RAT (SLC10A1)
| Species | Rattus norvegicus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Ananthanarayanan M,Ng OC,Boyer JL,Suchy FJ (1994) Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies., Am J Physiol, 267, G637-43. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 25 | Extracellular |
| 26 | 46 | Membrane |
| 47 | 59 | Cytoplasmic |
| 60 | 80 | Membrane |
| 81 | 87 | Extracellular |
| 88 | 108 | Membrane |
| 109 | 118 | Cytoplasmic |
| 119 | 140 | Membrane |
| 141 | 155 | Extracellular |
| 156 | 176 | Membrane |
| 177 | 189 | Cytoplasmic |
| 190 | 210 | Membrane |
| 211 | 221 | Extracellular |
| 222 | 242 | Membrane |
| 243 | 257 | Cytoplasmic |
| 258 | 274 | Membrane |
| 275 | 281 | Extracellular |
| 282 | 303 | Membrane |
| 304 | 362 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | BilAc:Na_symport/Acr3 |
| InterPro | Bilac:Na_transpt |
| InterPro | Na+/solute_symporter_sf |
| InterPro | SLC10A1 |
| Pfam | SBF |