Gene name
SLC17A3 (NPT4)
Experiment(s)
For this entry:
NPT4_HUMAN (SLC17A3)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Jutabha P,Anzai N,Kitamura K,Taniguchi A,Kaneko S,Yan K,Yamada H,Shimada H,Kimura T,Katada T,Fukutomi T,Tomita K,Urano W,Yamanaka H,Seki G,Fujita T,Moriyama Y,Yamada A,Uchida S,Wempe MF,Endou H,Sakurai H (2010) Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate., J Biol Chem, 285, 35123-32. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 125 | Cytoplasmic |
| 126 | 146 | Membrane |
| 147 | 153 | Extracellular |
| 154 | 174 | Membrane |
| 175 | 217 | Cytoplasmic |
| 218 | 239 | Membrane |
| 240 | 255 | Extracellular |
| 256 | 276 | Membrane |
| 277 | 291 | Cytoplasmic |
| 292 | 311 | Membrane |
| 312 | 316 | Extracellular |
| 317 | 337 | Membrane |
| 338 | 352 | Cytoplasmic |
| 353 | 373 | Membrane |
| 374 | 384 | Extracellular |
| 385 | 404 | Membrane |
| 405 | 420 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 355 | 23145083 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS |
| InterPro | MFS_dom |
| InterPro | MFS_trans_sf |
| InterPro | Na-dep_P-transpt_4_prd |
| Pfam | MFS_1 |