Gene name
SLC34A3 (NPT2C,NPTIIC)
Experiment(s)
For this entry:
NPT2C_MOUSE (SLC34A3)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Giral H,Lanzano L,Caldas Y,Blaine J,Verlander JW,Lei T,Gratton E,Levi M (2011) Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters., J Biol Chem, 286, 15032-42. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes | Only seen in a small subpopulation of proximal tubules. Apical localization depends on binding to NHERF |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 70 | Cytoplasmic |
| 71 | 92 | Membrane |
| 93 | 111 | Extracellular |
| 112 | 131 | Membrane |
| 132 | 192 | Cytoplasmic |
| 193 | 212 | Membrane |
| 213 | 323 | Extracellular |
| 324 | 345 | Membrane |
| 346 | 369 | Cytoplasmic |
| 370 | 391 | Membrane |
| 392 | 393 | Extracellular |
| 394 | 412 | Membrane |
| 413 | 414 | Cytoplasmic |
| 415 | 436 | Membrane |
| 437 | 447 | Extracellular |
| 448 | 467 | Membrane |
| 468 | 487 | Cytoplasmic |
| 488 | 508 | Membrane |
| 509 | 514 | Extracellular |
| 515 | 536 | Membrane |
| 537 | 601 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/Pi_transpt |
| InterPro | Na/Pi_transpt_2C |
| Pfam | Na_Pi_cotrans |