Gene name
SLC34A1 (SLC17A2,NPT2)
Experiment(s)
For this entry:
NPT2A_HUMAN (SLC34A1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Schlingmann KP,Ruminska J,Kaufmann M,Dursun I,Patti M,Kranz B,Pronicka E,Ciara E,Akcay T,Bulus D,Cornelissen EA,Gawlik A,Sikora P,Patzer L,Galiano M,Boyadzhiev V,Dumic M,Vivante A,Kleta R,Dekel B,Levtchenko E,Bindels RJ,Rust S,Forster IC,Hernando N,Jones G,Wagner CA,Konrad M (2016) Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia., J Am Soc Nephrol, 27, 604-14. [PubMed] [DOI] |
| Evidence level | Fluorescent tagging |
| Organ | Kidney |
| Cell | OK cells (proximal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 99 | Cytoplasmic |
| 100 | 121 | Membrane |
| 122 | 140 | Extracellular |
| 141 | 160 | Membrane |
| 161 | 223 | Cytoplasmic |
| 224 | 243 | Membrane |
| 244 | 348 | Extracellular |
| 349 | 370 | Membrane |
| 371 | 399 | Cytoplasmic |
| 400 | 427 | Membrane |
| 428 | 472 | Extracellular |
| 473 | 492 | Membrane |
| 493 | 512 | Cytoplasmic |
| 513 | 533 | Membrane |
| 534 | 539 | Extracellular |
| 540 | 561 | Membrane |
| 562 | 639 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 323 | N-GlycoSiteAtlas | ||
| 330 | N-GlycoSiteAtlas |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Na/Pi_transpt |
| InterPro | Na/Pi_transpt_2A |
| Pfam | Na_Pi_cotrans |