Gene name
SLC17A1 (Npt1,oatv1)
Experiment(s)
For this entry:
NPT1_HUMAN (SLC17A1)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Chiba T,Matsuo H,Kawamura Y,Nagamori S,Nishiyama T,Wei L,Nakayama A,Nakamura T,Sakiyama M,Takada T,Taketani Y,Suma S,Naito M,Oda T,Kumagai H,Moriyama Y,Ichida K,Shimizu T,Kanai Y,Shinomiya N (2015) NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout., Arthritis Rheumatol, 67, 281-7. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 20 | Cytoplasmic |
| 21 | 40 | Membrane |
| 41 | 80 | Extracellular |
| 81 | 101 | Membrane |
| 102 | 109 | Cytoplasmic |
| 110 | 130 | Membrane |
| 131 | 132 | Extracellular |
| 133 | 153 | Membrane |
| 154 | 172 | Cytoplasmic |
| 173 | 193 | Membrane |
| 194 | 200 | Extracellular |
| 201 | 220 | Membrane |
| 221 | 261 | Cytoplasmic |
| 262 | 283 | Membrane |
| 284 | 301 | Extracellular |
| 302 | 322 | Membrane |
| 323 | 338 | Cytoplasmic |
| 339 | 358 | Membrane |
| 359 | 363 | Extracellular |
| 364 | 384 | Membrane |
| 385 | 396 | Cytoplasmic |
| 397 | 418 | Membrane |
| 419 | 431 | Extracellular |
| 432 | 451 | Membrane |
| 452 | 467 | Cytoplasmic |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 74 | N-GlycoSiteAtlas |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MFS |
| InterPro | MFS_dom |
| InterPro | MFS_trans_sf |
| InterPro | Pi_cotranspt |
| Pfam | MFS_1 |