Gene name
Slc8a2 (KIAA1087,Ncx2)
Experiment(s)
For this entry:
NAC2_MOUSE (Slc8a2)
| Species | Mus musculus |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Gotoh Y,Kita S,Fujii M,Tagashira H,Horie I,Arai Y,Uchida S,Iwamoto T (2015) Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria., Biochem Biophys Res Commun, 456, 670-5. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Collecting ducts |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 21 | Signal peptide |
| 22 | 71 | Extracellular |
| 72 | 90 | Membrane |
| 91 | 163 | Cytoplasmic |
| 164 | 184 | Membrane |
| 185 | 197 | Extracellular |
| 198 | 218 | Membrane |
| 219 | 225 | Cytoplasmic |
| 226 | 246 | Membrane |
| 247 | 724 | Extracellular |
| 725 | 740 | Membrane |
| 741 | 748 | Cytoplasmic |
| 749 | 769 | Membrane |
| 770 | 822 | Extracellular |
| 823 | 843 | Membrane |
| 844 | 854 | Cytoplasmic |
| 855 | 875 | Membrane |
| 876 | 893 | Extracellular |
| 894 | 914 | Membrane |
| 915 | 921 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | CalX-like_sf |
| InterPro | Calx_beta |
| InterPro | Na_Ca_Ex |
| InterPro | Na_Ca_Ex_C-exten |
| InterPro | NaCa_Exmemb |
| Pfam | Calx-beta |
| Pfam | Na_Ca_ex |
| Pfam | Na_Ca_ex_C |