Gene name
Abcc6 (Mlp1,Mrp6,ARA)
Experiment(s)
For this entry:
MRP6_HUMAN (Abcc6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Sinkó E,Iliás A,Ujhelly O,Homolya L,Scheffer GL,Bergen AA,Sarkadi B,Váradi A (2003) Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells., Biochem Biophys Res Commun, 308, 263-9. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
MRP6_HUMAN (Abcc6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Hu X,Pijnenborg AC,Wijnholds J,Bergen AA,Scheper RJ (2002) MRP6 (ABCC6) detection in normal human tissues and tumors., Lab Invest, 82, 515-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Proximal tubules |
| Notes |
MRP6_HUMAN (Abcc6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Scheffer GL,Hu X,Pijnenborg AC,Wijnholds J,Bergen AA,Scheper RJ (2002) MRP6 (ABCC6) detection in normal human tissues and tumors., Lab Invest, 82, 515-8. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | Hepatocytes |
| Notes |
MRP6_HUMAN (Abcc6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Sinkó E,Iliás A,Ujhelly O,Homolya L,Scheffer GL,Bergen AA,Sarkadi B,Váradi A (2003) Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells., Biochem Biophys Res Commun, 308, 263-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 34 | Extracellular |
| 35 | 55 | Membrane |
| 56 | 72 | Cytoplasmic |
| 73 | 91 | Membrane |
| 92 | 103 | Extracellular |
| 104 | 124 | Membrane |
| 125 | 133 | Cytoplasmic |
| 134 | 153 | Membrane |
| 154 | 166 | Extracellular |
| 167 | 186 | Membrane |
| 187 | 305 | Cytoplasmic |
| 306 | 326 | Membrane |
| 327 | 348 | Extracellular |
| 349 | 367 | Membrane |
| 368 | 424 | Cytoplasmic |
| 425 | 445 | Membrane |
| 446 | 450 | Extracellular |
| 451 | 469 | Membrane |
| 470 | 533 | Cytoplasmic |
| 534 | 554 | Membrane |
| 555 | 566 | Extracellular |
| 567 | 584 | Membrane |
| 585 | 940 | Cytoplasmic |
| 941 | 961 | Membrane |
| 962 | 989 | Extracellular |
| 990 | 1010 | Membrane |
| 1011 | 1062 | Cytoplasmic |
| 1063 | 1083 | Membrane |
| 1084 | 1085 | Extracellular |
| 1086 | 1105 | Membrane |
| 1106 | 1169 | Cytoplasmic |
| 1170 | 1189 | Membrane |
| 1190 | 1199 | Extracellular |
| 1200 | 1217 | Membrane |
| 1218 | 1503 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC6 |
| InterPro | Multidrug-R_assoc |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |