Gene name
ABCC5 (Mrp5,Abcc5a)
Experiment(s)
For this entry:
MRP5_HUMAN (ABCC5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Nies AT,Jedlitschky G,König J,Herold-Mende C,Steiner HH,Schmitt HP,Keppler D (2004) Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain., Neuroscience, 129, 349-60. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
MRP5_HUMAN (ABCC5)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Meyer Zu Schwabedissen HE,Grube M,Heydrich B,Linnemann K,Fusch C,Kroemer HK,Jedlitschky G (2005) Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation., Am J Pathol, 166, 39-48. [PubMed] [DOI] |
| Evidence level | Membrane preparation |
| Organ | Placenta |
| Cell | Trophoblast cells |
| Notes |
MRP5_HUMAN (ABCC5)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D (2005) Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma., Int J Cancer, 115, 359-67. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Pancreas |
| Cell | Ductal cells |
| Notes |
MRP5_HUMAN (ABCC5)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Bronger H,König J,Kopplow K,Steiner HH,Ahmadi R,Herold-Mende C,Keppler D,Nies AT (2005) ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier., Cancer Res, 65, 11419-28. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 178 | Cytoplasmic |
| 179 | 199 | Membrane |
| 200 | 215 | Extracellular |
| 216 | 236 | Membrane |
| 237 | 290 | Cytoplasmic |
| 291 | 311 | Membrane |
| 312 | 316 | Extracellular |
| 317 | 336 | Membrane |
| 337 | 399 | Cytoplasmic |
| 400 | 420 | Membrane |
| 421 | 427 | Extracellular |
| 428 | 447 | Membrane |
| 448 | 853 | Cytoplasmic |
| 854 | 874 | Membrane |
| 875 | 914 | Extracellular |
| 915 | 936 | Membrane |
| 937 | 991 | Cytoplasmic |
| 992 | 1011 | Membrane |
| 1012 | 1013 | Extracellular |
| 1014 | 1033 | Membrane |
| 1034 | 1101 | Cytoplasmic |
| 1102 | 1120 | Membrane |
| 1121 | 1127 | Extracellular |
| 1128 | 1147 | Membrane |
| 1148 | 1437 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 10 | 2424935 |
| 14 | 15417463 |
| 17 | 15228655 |
| 19 | 10999278 |
| 60 | 31080952 |
| 64 | 34669190 |
| 67 | 34669193 |
| 351 | 23078387 |
| 485 | 36125139 |
| 501 | 4785037 |
| 505 | 3175004 |
| 509 | 3175007 |
| 513 | 3175010 |
| 553 | 36126968 |
| 558 | 18908436 |
| 686 | 18908433 |
| 800 | 10827341 |
| 807 | 10827345 |
| 814 | 10827349 |
| 1166 | 3974642 |
| 1202 | 472662 |
| 1216 | 25279316 |
| 1268 | 23078384 |
| 1423 | 40434085 |
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 890 | N-GlycoSiteAtlas | 24190977 | |
| 890 | PolarProtDb | 31844046 | |
| 897 | N-GlycoSiteAtlas | 24190977 | |
| 897 | PolarProtDb | 31844046 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | ABCC5 |
| InterPro | P-loop_NTPase |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| TMM17_HUMAN | 2 | 26638075 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.