Gene name
SLC16A2 (Mct8,Xpct)
Experiment(s)
For this entry:
MOT8_RAT (SLC16A2)
| Species | Rattus norvegicus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Roberts LM,Woodford K,Zhou M,Black DS,Haggerty JE,Tate EH,Grindstaff KK,Mengesha W,Raman C,Zerangue N (2008) Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier., Endocrinology, 149, 6251-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Vessels |
| Cell | Brain capillary endothelial cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 104 | Cytoplasmic |
| 105 | 124 | Membrane |
| 125 | 148 | Extracellular |
| 149 | 170 | Membrane |
| 171 | 177 | Cytoplasmic |
| 178 | 197 | Membrane |
| 198 | 204 | Extracellular |
| 205 | 225 | Membrane |
| 226 | 234 | Cytoplasmic |
| 235 | 256 | Membrane |
| 257 | 265 | Extracellular |
| 266 | 286 | Membrane |
| 287 | 326 | Cytoplasmic |
| 327 | 348 | Membrane |
| 349 | 362 | Extracellular |
| 363 | 383 | Membrane |
| 384 | 392 | Cytoplasmic |
| 393 | 413 | Membrane |
| 414 | 417 | Extracellular |
| 418 | 438 | Membrane |
| 439 | 452 | Cytoplasmic |
| 453 | 474 | Membrane |
| 475 | 484 | Extracellular |
| 485 | 506 | Membrane |
| 507 | 545 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | MCT8 |
| InterPro | MFS |
| InterPro | MFS_dom |
| InterPro | MFS_trans_sf |
| Pfam | MFS_1 |