Gene name
ABCB4 (Mdr2,Pgy-2,Pgy2,MDR3,PGY3)
Experiment(s)
For this entry:
MDR3_HUMAN (ABCB4)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
van Helvoort A,Smith AJ,Sprong H,Fritzsche I,Schinkel AH,Borst P,van Meer G (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine., Cell, 87, 507-17. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | LLC-PK1 cells (proximal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 50 | Cytoplasmic |
| 51 | 75 | Membrane |
| 76 | 120 | Extracellular |
| 121 | 141 | Membrane |
| 142 | 188 | Cytoplasmic |
| 189 | 210 | Membrane |
| 211 | 217 | Extracellular |
| 218 | 238 | Membrane |
| 239 | 294 | Cytoplasmic |
| 295 | 316 | Membrane |
| 317 | 335 | Extracellular |
| 336 | 357 | Membrane |
| 358 | 710 | Cytoplasmic |
| 711 | 732 | Membrane |
| 733 | 755 | Extracellular |
| 756 | 776 | Membrane |
| 777 | 829 | Cytoplasmic |
| 830 | 850 | Membrane |
| 851 | 857 | Extracellular |
| 858 | 878 | Membrane |
| 879 | 932 | Cytoplasmic |
| 933 | 954 | Membrane |
| 955 | 975 | Extracellular |
| 976 | 994 | Membrane |
| 995 | 1286 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 91 | N-GlycoSiteAtlas | 24495048 | |
| 91 | UniPep | ||
| 97 | N-GlycoSiteAtlas | 24495048 | |
| 97 | UniPep |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | AAA+_ATPase |
| InterPro | ABC1_TM_dom |
| InterPro | ABC1_TM_sf |
| InterPro | ABC_transporter-like |
| InterPro | ABC_transporter_CS |
| InterPro | MDR3 |
| InterPro | P-loop_NTPase |
| InterPro | Type_I_exporter |
| Pfam | ABC_membrane |
| Pfam | ABC_tran |