Gene name
MAL2 (Mal2A)
Experiment(s)
For this entry:
MAL2_HUMAN (MAL2)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
de Marco MC,Martín-Belmonte F,Kremer L,Albar JP,Correas I,Vaerman JP,Marazuela M,Byrne JA,Alonso MA (2002) MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells., J Cell Biol, 159, 37-44. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Liver |
| Cell | HEPG2 cells (hepatocytes) |
| Notes | Most of the protein is actually in the apical recycling endosome - not on surface |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 34 | Cytoplasmic |
| 35 | 55 | Membrane |
| 56 | 66 | Extracellular |
| 67 | 88 | Membrane |
| 89 | 102 | Cytoplasmic |
| 103 | 123 | Membrane |
| 124 | 149 | Extracellular |
| 150 | 171 | Membrane |
| 172 | 176 | Cytoplasmic |
Glycosylation
Family and domain data
Interactions
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.