Gene name
ADAM10 (Kuz,Madm)
Experiment(s)
For this entry:
M1VKS2_CANLF (ADAM10)
| Species | Canis lupus familiaris |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Caceres PS,Gravotta D,Zager PJ,Dephoure N,Rodriguez-Boulan E (2019) Quantitative proteomics of MDCK cells identify unrecognized roles of clathrin adaptor AP-1 in polarized distribution of surface proteins., Proc Natl Acad Sci U S A, 116, 11796-11805. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 19 | Signal peptide |
| 20 | 672 | Extracellular |
| 673 | 695 | Membrane |
| 696 | 747 | Cytoplasmic |
Eukaryotic Linear Motif (ELM)
| Start | End | Sequence | Motif |
|---|---|---|---|
| 720 | 723 | KRRR | TRG_ER_diArg_1 |
| 744 | 747 | HMRR | TRG_ER_diArg_1 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | ADAM10_ADAM17 |
| InterPro | ADAM_10 |
| InterPro | Disintegrin_dom |
| InterPro | Disintegrin_dom_sf |
| InterPro | MetalloPept_cat_dom_sf |
| InterPro | Peptidase_M12B |
| InterPro | Peptidase_M12B_N |
| Pfam | Disintegrin |
| Pfam | Pep_M12B_propep |