Gene name
LHCGR (LCGR,LGR2,LHRHR,Lhr,LHCGR)
Experiment(s)
For this entry:
LSHR_PIG (LHCGR)
| Species | Sus scrofa |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Beau I,Groyer-Picard MT,Desroches A,Condamine E,Leprince J,Tomé JP,Dessen P,Vaudry H,Misrahi M (2004) The basolateral sorting signals of the thyrotropin and luteinizing hormone receptors: an unusual family of signals sharing an unusual distal intracellular localization, but unrelated in their structures., Mol Endocrinol, 18, 733-46. [PubMed] [DOI] |
| Evidence level | Antibody staining + sub-protein manipulation |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Localization was mediated by the cytoplasmic tail |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 23 | Signal peptide |
| 24 | 371 | Extracellular |
| 372 | 387 | Membrane |
| 388 | 396 | Cytoplasmic |
| 397 | 418 | Membrane |
| 419 | 441 | Extracellular |
| 442 | 462 | Membrane |
| 463 | 482 | Cytoplasmic |
| 483 | 503 | Membrane |
| 504 | 526 | Extracellular |
| 527 | 547 | Membrane |
| 548 | 570 | Cytoplasmic |
| 571 | 592 | Membrane |
| 593 | 605 | Extracellular |
| 606 | 626 | Membrane |
| 627 | 696 | Cytoplasmic |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | GPCR_Rhodpsn |
| InterPro | GPCR_Rhodpsn_7TM |
| InterPro | Gphrmn_rcpt_fam |
| InterPro | LRR_5 |
| InterPro | LRR_dom_sf |
| InterPro | LSH_rcpt |
| Pfam | 7tm_1 |
| Pfam | LRR_5 |