Gene name
Kl
Experiment(s)
For this entry:
KLOT_MOUSE (Kl)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Li SA,Watanabe M,Yamada H,Nagai A,Kinuta M,Takei K (2004) Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice., Cell Struct Funct, 29, 91-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Choroid plexus |
| Cell | Ependymal cells |
| Notes |
KLOT_MOUSE (Kl)
| Species | Mus musculus |
|---|---|
| Localization | Non polar membrane |
| Reference |
Li SA,Watanabe M,Yamada H,Nagai A,Kinuta M,Takei K (2004) Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice., Cell Struct Funct, 29, 91-9. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 35 | Signal peptide |
| 36 | 983 | Extracellular |
| 984 | 1004 | Membrane |
| 1005 | 1014 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Glyco_hydro_1 |
| InterPro | Glyco_hydro_1_N_CS |
| InterPro | Glycoside_hydrolase_SF |
| InterPro | Klotho |
| Pfam | Glyco_hydro_1 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| WNT3_MOUSE | 4 | 17690294 |
| WNT4_MOUSE | 2 | 17690294 |
| WNT5A_MOUSE | 2 | 17690294 |
| WNT1_MOUSE | 2 | 17690294 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.