Gene name
Kcnq1 (KCNA8,Kcna9,Kvlqt1)
Experiment(s)
For this entry:
KCNQ1_MOUSE (Kcnq1)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Estévez R,Boettger T,Stein V,Birkenhäger R,Otto E,Hildebrandt F,Jentsch TJ (2001) Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion., Nature, 414, 558-61. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Inner ear |
| Cell | Vascular stria cells |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 120 | Cytoplasmic |
| 121 | 141 | Membrane |
| 142 | 153 | Extracellular |
| 154 | 172 | Membrane |
| 173 | 196 | Cytoplasmic |
| 197 | 216 | Membrane |
| 217 | 260 | Extracellular |
| 261 | 281 | Membrane |
| 282 | 294 | Cytoplasmic |
| 295 | 314 | Membrane |
| 315 | 326 | Extracellular |
| 327 | 352 | Membrane |
| 353 | 668 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | Ion_trans_dom |
| InterPro | K_chnl_volt-dep_KCNQ |
| InterPro | K_chnl_volt-dep_KCNQ_C |
| InterPro | K_chnl_volt-dep_KCQN1 |
| InterPro | VG_K_chnl |
| Pfam | Ion_trans |
| Pfam | KCNQ_channel |