Gene name
KCNA1
Experiment(s)
For this entry:
KCNA1_MOUSE (KCNA1)
| Species | Mus musculus |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Glaudemans B,van der Wijst J,Scola RH,Lorenzoni PJ,Heister A,van der Kemp AW,Knoers NV,Hoenderop JG,Bindels RJ (2009) A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia., J Clin Invest, 119, 936-42. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | Distal tubules |
| Notes |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 167 | Cytoplasmic |
| 168 | 186 | Membrane |
| 187 | 220 | Extracellular |
| 221 | 238 | Membrane |
| 239 | 253 | Cytoplasmic |
| 254 | 271 | Membrane |
| 272 | 284 | Extracellular |
| 285 | 300 | Membrane |
| 301 | 329 | Cytoplasmic |
| 330 | 345 | Membrane |
| 346 | 362 | Extracellular |
| 363 | 375 | Re-entrant loop |
| 376 | 383 | Extracellular |
| 384 | 401 | Membrane |
| 402 | 495 | Cytoplasmic |
Phosphorylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | BTB/POZ_dom |
| InterPro | Ion_trans_dom |
| InterPro | K_chnl_volt-dep_Kv |
| InterPro | K_chnl_volt-dep_Kv1 |
| InterPro | K_chnl_volt-dep_Kv1.1 |
| InterPro | SKP1/BTB/POZ_sf |
| InterPro | T1-type_BTB |
| InterPro | VG_K_chnl |
| InterPro | Volt_channel_dom_sf |
| Pfam | BTB_2 |
| Pfam | Ion_trans |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| DLG4_MOUSE | 4 | 19022416 , 28671696 , 19455133 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.