Gene name
ITGB4
Experiment(s)
For this entry:
ITB4_HUMAN (ITGB4)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Mammary gland |
| Cell | MCF10A cells (acinar cells) |
| Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 27 | Signal peptide |
| 28 | 712 | Extracellular |
| 713 | 733 | Membrane |
| 734 | 1822 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 293 | O-GlycoProteomDB | ||
| 327 | N-GlycoSiteAtlas | 26571101 | |
| 327 | PolarProtDb | 31844046 | |
| 491 | N-GlycoSiteAtlas | 26571101 | |
| 491 | UniPep | ||
| 695 | dbPTM | 16335952 | |
| 695 | N-GlycoSiteAtlas | 24495048 | |
| 695 | PolarProtDb | 31844046 | |
| 695 | UniProtKB | 16335952 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | CalX-like_sf |
| InterPro | Calx_beta |
| InterPro | EGF-like_dom |
| InterPro | EGF_extracell |
| InterPro | FN3_dom |
| InterPro | FN3_sf |
| InterPro | I-EGF_1 |
| InterPro | Ig-like_fold |
| InterPro | Integrin_beta_N |
| InterPro | Integrin_bsu |
| InterPro | Integrin_bsu-4 |
| InterPro | Integrin_bsu_tail |
| InterPro | Integrin_bsu_tail_dom_sf |
| InterPro | Integrin_bsu_VWA |
| InterPro | PSI |
| InterPro | vWFA_dom_sf |
| Pfam | Calx-beta |
| Pfam | EGF_2 |
| Pfam | fn3 |
| Pfam | I-EGF_1 |
| Pfam | Integrin_B_tail |
| Pfam | Integrin_beta |
| Pfam | PSI_integrin |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| S1PR2_HUMAN | 2 | 24851274 |
| S1PR3_HUMAN | 3 | 24851274 |
| CD151_HUMAN | 2 | 10811835 |
| ITA6_HUMAN | 3 | 2649503 , 21880726 |
| CADM1_MOUSE | 3 | 21880726 |
| LOX12_HUMAN | 2 | 10727209 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.