Gene name
ITGA6
Experiment(s)
For this entry:
ITA6_HUMAN (ITGA6)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Mammary gland |
| Cell | MCF10A cells (acinar cells) |
| Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 23 | Signal peptide |
| 24 | 1055 | Extracellular |
| 1056 | 1075 | Membrane |
| 1076 | 1130 | Cytoplasmic |
Phosphorylation
| Position | Resource |
|---|---|
| 13 | 3652631 |
| 85 | 3652634 |
| 89 | 3652637 |
| 187 | 3652640 |
| 202 | 55371284 |
| 317 | 3652643 |
| 379 | 55371288 |
| 512 | 3652646 |
| 560 | 3652649 |
| 588 | 3652652 |
| 592 | 3652655 |
| 624 | 3652658 |
| 632 | 3652661 |
| 648 | 3652664 |
| 716 | 3652667 |
| 722 | 3652670 |
| 742 | 155354784 |
| 750 | 17400248 |
| 752 | 17402333 |
| 825 | 3652673 |
| 871 | 55371292 |
| 887 | 5887242 |
| 889 | 5887250 |
| 899 | 480618 |
| 932 | 3652676 |
| 934 | 3652679 |
| 937 | 3652682 |
| 955 | 27451091 |
| 1009 | 55371296 |
| 1043 | 451206 |
| 1045 | 3652685 |
| 1110 | 3479098 |
| 1129 | 6139400 |
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | FG-GAP |
| InterPro | Int_alpha_beta-p |
| InterPro | Integrin_alpha |
| InterPro | Integrin_alpha-2 |
| InterPro | Integrin_alpha_C_CS |
| InterPro | Integrin_alpha_N |
| InterPro | Integrin_dom_sf |
| Pfam | FG-GAP |
| Pfam | Integrin_alpha2 |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| CD151_HUMAN | 2 | 10811835 |
| ITB4_HUMAN | 3 | 2649503 , 21880726 |
| TMM17_HUMAN | 2 | 26638075 |
| CD81_HUMAN | 3 | 30024968 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.