Gene name
ITGA6
Experiment(s)
For this entry:
ITA6_HUMAN (ITGA6)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
Evidence level | Large-scale proteomics |
Organ | Mammary gland |
Cell | MCF10A cells (acinar cells) |
Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 23 | Signal peptide |
24 | 1055 | Extracellular |
1056 | 1075 | Membrane |
1076 | 1130 | Cytoplasmic |
Phosphorylation
Position | Resource |
---|---|
13 | 3652631 |
85 | 3652634 |
89 | 3652637 |
187 | 3652640 |
202 | 55371284 |
317 | 3652643 |
379 | 55371288 |
512 | 3652646 |
560 | 3652649 |
588 | 3652652 |
592 | 3652655 |
624 | 3652658 |
632 | 3652661 |
648 | 3652664 |
716 | 3652667 |
722 | 3652670 |
742 | 155354784 |
750 | 17400248 |
752 | 17402333 |
825 | 3652673 |
871 | 55371292 |
887 | 5887242 |
889 | 5887250 |
899 | 480618 |
932 | 3652676 |
934 | 3652679 |
937 | 3652682 |
955 | 27451091 |
1009 | 55371296 |
1043 | 451206 |
1045 | 3652685 |
1110 | 3479098 |
1129 | 6139400 |
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | FG-GAP |
InterPro | Int_alpha_beta-p |
InterPro | Integrin_alpha |
InterPro | Integrin_alpha-2 |
InterPro | Integrin_alpha_C_CS |
InterPro | Integrin_alpha_N |
InterPro | Integrin_dom_sf |
Pfam | FG-GAP |
Pfam | Integrin_alpha2 |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
CD151_HUMAN | 2 | 10811835 |
ITB4_HUMAN | 3 | 2649503 , 21880726 |
TMM17_HUMAN | 2 | 26638075 |
CD81_HUMAN | 3 | 30024968 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.