Gene name
ITGA2 (CD49B)
Experiment(s)
For this entry:
ITA2_HUMAN (ITGA2)
| Species | Homo sapiens |
|---|---|
| Localization | Basolateral plasma membrane |
| Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
| Evidence level | Large-scale proteomics |
| Organ | Mammary gland |
| Cell | MCF10A cells (acinar cells) |
| Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 29 | Signal peptide |
| 30 | 1131 | Extracellular |
| 1132 | 1153 | Membrane |
| 1154 | 1181 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | FG-GAP |
| InterPro | Int_alpha_beta-p |
| InterPro | Integrin_alpha |
| InterPro | Integrin_alpha-2 |
| InterPro | Integrin_alpha_C_CS |
| InterPro | Integrin_alpha_N |
| InterPro | Integrin_dom_sf |
| InterPro | VWF_A |
| InterPro | vWFA_dom_sf |
| Pfam | FG-GAP |
| Pfam | Integrin_alpha2 |
| Pfam | VWA |
Interactions
| With (links to EBI) | #Exp | PubMed links |
|---|---|---|
| ITB1_HUMAN | 3 | 21947080 , 14681217 |
| ITA2_HUMAN | 2 | 14681217 |
| SHRPN_HUMAN | 5 | 21947080 |
| RAB21_MOUSE | 7 | 16754960 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.