Gene name
ITGA2 (CD49B)
Experiment(s)
For this entry:
ITA2_HUMAN (ITGA2)
Species | Homo sapiens |
---|---|
Localization | Basolateral plasma membrane |
Reference |
Chin AR,Yan W,Cao M,Liu X,Wang SE (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia., J Mammary Gland Biol Neoplasia, 23, 165-176. [PubMed] [DOI] |
Evidence level | Large-scale proteomics |
Organ | Mammary gland |
Cell | MCF10A cells (acinar cells) |
Notes | Detected in the polarized exosome fraction |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start | End | Localisation |
---|---|---|
1 | 29 | Signal peptide |
30 | 1131 | Extracellular |
1132 | 1153 | Membrane |
1154 | 1181 | Cytoplasmic |
Phosphorylation
Glycosylation
Family and domain data
Database | Domain/Family name |
---|---|
InterPro | FG-GAP |
InterPro | Int_alpha_beta-p |
InterPro | Integrin_alpha |
InterPro | Integrin_alpha-2 |
InterPro | Integrin_alpha_C_CS |
InterPro | Integrin_alpha_N |
InterPro | Integrin_dom_sf |
InterPro | VWF_A |
InterPro | vWFA_dom_sf |
Pfam | FG-GAP |
Pfam | Integrin_alpha2 |
Pfam | VWA |
Interactions
With (links to EBI) | #Exp | PubMed links |
---|---|---|
ITB1_HUMAN | 3 | 21947080 , 14681217 |
ITA2_HUMAN | 2 | 14681217 |
SHRPN_HUMAN | 5 | 21947080 |
RAB21_MOUSE | 7 | 16754960 |
Protein can be found in apical membrane,
Protein can be found in basal membrane,
Protein can be found both membranes,
Localisation is unknown.