Gene name

INSR

Experiment(s)

For this entry:
INSR_RAT (INSR)
Species Rattus norvegicus
Localization Basolateral plasma membrane
Reference Sugasawa K,Deguchi J,Okami T,Yamamoto A,Omori K,Uyama M,Tashiro Y (1994) Immunocytochemical analyses of distributions of Na, K-ATPase and GLUT1, insulin and transferrin receptors in the developing retinal pigment epithelial cells., Cell Struct Funct, 19, 21-8.
[PubMed] [DOI]
Evidence level Antibody staining
Organ Retina
Cell Pigment epithel cells
Notes
For ortholog entries:
INSR_HUMAN

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
Start End Localisation
1 27 Signal peptide
28 959 Extracellular
960 980 Membrane
981 1383 Cytoplasmic
Phosphorylation
Position Resource
1000 447685
1034 454090
1186 447680
1190 447681
1191 447682
1351 29576994
1356 447683
1362 447684
1376 450327
Glycosylation
Position Site resource Glycan resource PubMed link(s)
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23302862
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 25092300
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26853939
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 27281820
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29512653
42 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 29512653
51 PDB WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1 23302862
51 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
51 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 25092300
51 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23302862
51 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 16894147
51 PDB WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b4-c1 26027733
51 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 29512653
51 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 26853939
51 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 27281820
51 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 29512653
137 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1 26853939
137 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1 29512653
137 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1 29512653
137 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 27281820
137 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
137 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
137 PDB WURCS=2.0/3,6,5/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3/a4-b1_b4-c1_c3-d1_c6-f1_d2-e1 16894147
137 PDB WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3/a4-b1_b4-c1_c3-d1 23302862
137 PDB WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3/a4-b1_b4-c1_c3-d1 25092300
241 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 23302862
241 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 25092300
241 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
241 PDB WURCS=2.0/3,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-e1_e3-f1_e6-g1 16894147
241 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 27281820
241 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26853939
241 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
281 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 29512653
281 PDB WURCS=2.0/4,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5][a1221m-1a_1-5]/1-1-2-3-1-3-4/a4-b1_a6-g1_b4-c1_c3-d1_c6-f1_d2-e1 27281820
281 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1 23302862
281 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 26027733
281 PDB WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1 26027733
281 PDB WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b4-c1 25092300
281 PDB WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b4-c1 16894147
281 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 29512653
281 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 26853939
321 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26027733
363 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 16894147
423 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 16894147
423 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 29512653
423 PDB WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1 29512653
423 PDB WURCS=2.0/4,6,5/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5][a1221m-1a_1-5]/1-1-2-3-1-4/a4-b1_a6-f1_b4-c1_c6-d1_d2-e1 26853939
444 PDB WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1 29512653
444 PDB WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1 29512653
444 PDB WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1 26853939
444 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 16894147
540 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 23302862
540 PDB WURCS=2.0/1,1,0/[a2122h-1b_1-5_2*NCC/3=O]/1/ 26853939
634 PDB WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1 26853939
921 UniCarbKB WURCS=2.0/2,7,6/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2-2-2-2/a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g?_a?|b?|c?|d?|e?|f?|g?}-{a?|b?|c?|d?|e?|f?|g? 24090084
921 UniCarbKB WURCS=2.0/3,9,8/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-f1_d2-e1_g2-h1_g1-f3|f6_i1-f3|f6 24090084
921 UniCarbKB WURCS=2.0/2,9,8/[uxxxxh_2*NCC/3=O][uxxxxh]/1-1-2-2-2-2-2-2-2/a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i?_a?|b?|c?|d?|e?|f?|g?|h?|i?}-{a?|b?|c?|d?|e?|f?|g?|h?|i? 24090084
921 UniCarbKB WURCS=2.0/3,9,8/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-e1_e3-f1_e6-h1_f2-g1_h2-i1 24090084
921 UniCarbKB WURCS=2.0/3,7,6/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3-3-3/a4-b1_b4-c1_c3-d1_c6-e1_e3-f1_e6-g1 24090084
921 PDB WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1 26853939

Family and domain data

Database Domain/Family name
InterPro FN3_dom
InterPro FN3_sf
InterPro Furin-like_Cys-rich_dom
InterPro Furin_repeat
InterPro Growth_fac_rcpt_cys_sf
InterPro Ig-like_fold
InterPro Insulin_TMD
InterPro Kinase-like_dom_sf
InterPro Prot_kinase_dom
InterPro Protein_kinase_ATP_BS
InterPro Rcpt_L-dom
InterPro Rcpt_L-dom_sf
InterPro Ser-Thr/Tyr_kinase_cat_dom
InterPro Tyr_kinase_AS
InterPro Tyr_kinase_cat_dom
InterPro Tyr_kinase_insulin-like_rcpt
InterPro Tyr_kinase_rcpt_2_CS
Pfam fn3
Pfam Furin-like
Pfam Insulin_TMD
Pfam PK_Tyr_Ser-Thr
Pfam Recep_L_domain

Interactions

With (links to EBI) #Exp PubMed links
G3V836_RAT 2 30300385
ASGR1_RAT 2 30300385
PDIA1_RAT 2 30300385
AT1A1_RAT 2 30300385
F1LQ81_RAT 2 30300385
G3V8X4_RAT 2 30300385
D4A3M8_RAT 2 30300385
D3ZJZ0_RAT 2 30300385
CP2C6_RAT 2 30300385
SC22B_RAT 2 30300385
E9PU24_RAT 2 30300385
SNAA_RAT 2 30300385
A7LNF8_RAT 2 30300385
G3V824_RAT 2 30300385
D3ZN27_RAT 2 30300385
M0RCY2_RAT 2 30300385
PDIA3_RAT 2 30300385
DHE3_RAT 2 30300385
TFR1_RAT 2 30300385
F1M1B3_RAT 2 30300385
CCD93_RAT 2 30300385
APOB_RAT 2 30300385
RL18_RAT 2 30300385
D3ZCF8_RAT 2 30300385
F1LNL0_RAT 2 30300385
D3ZDS2_RAT 2 30300385
M0R930_RAT 2 30300385
SO1B2_RAT 2 30300385
VP35L_RAT 2 30300385
RB11A_RAT 2 30300385
D3Z8D7_RAT 2 30300385
D3ZBS2_RAT 2 30300385
D4AE06_RAT 2 30300385
CDC42_RAT 2 30300385
G3V6Z7_RAT 2 30300385
PON1_RAT 2 30300385
B0BMW0_RAT 2 30300385
SCAM1_RAT 2 30300385
RDH7_RAT 2 30300385
M0R9C6_RAT 2 30300385
NSDHL_RAT 2 30300385
G3V6D3_RAT 2 30300385
F1LQS3_RAT 2 30300385
G3V6K0_RAT 2 30300385
ENPL_RAT 2 30300385
F1LM19_RAT 2 30300385
D3ZC56_RAT 2 30300385
G3V680_RAT 2 30300385
Q4QQW7_RAT 2 30300385
D3ZRM9_RAT 2 30300385
TFR2_RAT 2 30300385
TMED9_RAT 2 30300385
M0R4A0_RAT 2 30300385
REEP6_RAT 2 30300385
B0BNK1_RAT 2 30300385
M0RBF1_RAT 2 30300385
D3ZX87_RAT 2 30300385
PLMN_RAT 2 30300385
D3ZUD8_RAT 2 30300385
HRG_RAT 2 30300385
MGST1_RAT 2 30300385
COPD_RAT 2 30300385
M0R506_RAT 2 30300385
B2RYP4_RAT 2 30300385
Q80ZA3_RAT 2 30300385
TMED2_RAT 2 30300385
RAB6A_RAT 2 30300385
PPIB_RAT 2 30300385
B2RYN6_RAT 2 30300385
VAMP3_RAT 2 30300385
RL24_RAT 2 30300385
CCD22_RAT 2 30300385
HYEP_RAT 2 30300385
S27A5_RAT 2 30300385
G3V8R1_RAT 2 30300385
B1WBS4_RAT 2 30300385
CP2DQ_RAT 2 30300385
D3ZTK5_RAT 2 30300385
D3Z8W1_RAT 2 30300385
COPG1_RAT 2 30300385
INSR_RAT 3 30300385
ACTB_RAT 2 30300385
EF1A1_RAT 2 30300385
D3ZEN2_RAT 2 30300385
M0R890_RAT 2 30300385
Q64648_RAT 2 30300385
G3V8A5_RAT 2 30300385
MANF_RAT 2 30300385
Q68FX4_RAT 2 30300385
FINC_RAT 2 30300385
BIP_RAT 2 30300385
B0BNG3_RAT 2 30300385
ASGR2_RAT 2 30300385
CP2D1_RAT 2 30300385
RLA0_RAT 2 30300385
MRP2_RAT 2 30300385
SIGIR_RAT 2 30300385
VPP1_RAT 2 30300385
M0R5T4_RAT 2 30300385
TECR_RAT 2 30300385
DHB13_RAT 2 30300385
Q6PDV8_RAT 2 30300385
F1LUA1_RAT 2 30300385
E9PSP8_RAT 2 30300385
G3V7V6_RAT 2 30300385
TMED7_RAT 2 30300385
APOE_RAT 2 30300385
F1LNT1_RAT 2 30300385
F1LNT8_RAT 2 30300385
G3V9N9_RAT 2 30300385
G3V9N8_RAT 2 30300385
ECHP_RAT 2 30300385
G3V8D4_RAT 2 30300385
D4A7I6_RAT 2 30300385
HEMO_RAT 2 30300385
G3V9W6_RAT 2 30300385
M0RCH6_RAT 2 30300385
F1LRA1_RAT 2 30300385
G3V699_RAT 2 30300385
CPSM_RAT 2 30300385
HPT_RAT 2 30300385
NTCP_RAT 2 30300385
D3ZAS1_RAT 2 30300385
B5DFC3_RAT 2 30300385
GOGA2_RAT 2 30300385
SPA3K_RAT 2 30300385
D4A1B2_RAT 2 30300385
RER1_RAT 2 30300385
D4A563_RAT 2 30300385
F1M2B6_RAT 2 30300385
ACSL1_RAT 2 30300385
PDIA6_RAT 2 30300385
D4A1D8_RAT 2 30300385
NUCB1_RAT 2 30300385
Q5RKJ9_RAT 2 30300385
RAB7A_RAT 2 30300385
T176B_RAT 2 30300385
B0BMY2_RAT 2 30300385
APOA1_RAT 2 30300385
APOA5_RAT 2 30300385
IRGM_RAT 2 30300385
B3SVE6_RAT 2 30300385
PGRC1_RAT 2 30300385
D3ZKL4_RAT 2 30300385
CP2B3_RAT 2 30300385
CP2A1_RAT 2 30300385
NXPE4_RAT 2 30300385
B0K031_RAT 2 30300385
WASH1_RAT 2 30300385
FAAH1_RAT 2 30300385
D3ZD31_RAT 2 30300385
LRP1_RAT 2 30300385
CP2CN_RAT 2 30300385
ACSL5_RAT 2 30300385
LONM_RAT 2 30300385
CP1A2_RAT 2 30300385
NB5R3_RAT 2 30300385
TMEDA_RAT 2 30300385
G3V6Q2_RAT 2 30300385
ALBU_RAT 2 30300385
G3V6H0_RAT 2 30300385
C1QC_RAT 2 30300385
M0R8M9_RAT 2 30300385
G3V856_RAT 2 30300385
Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.

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