Gene name
IL2RA (Il2r)
Experiment(s)
For this entry:
IL2RA_HUMAN (IL2RA)
| Species | Homo sapiens |
|---|---|
| Localization | Apical plasma membrane |
| Reference |
Iverson HA,Fox D 3rd,Nadler LS,Klevit RE,Nathanson NM (2005) Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal., J Biol Chem, 280, 24568-75. [PubMed] [DOI] |
| Evidence level | Antibody staining |
| Organ | Kidney |
| Cell | MDCK cells (distal tubule) |
| Notes | Proteins were tagged by FLAG-tag for labelling |
For ortholog entries:
Alignment and sequence features
Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).
CCTOP topology prediction
| Start | End | Localisation |
|---|---|---|
| 1 | 21 | Signal peptide |
| 22 | 244 | Extracellular |
| 245 | 260 | Membrane |
| 261 | 272 | Cytoplasmic |
Phosphorylation
Glycosylation
| Position | Site resource | Glycan resource | PubMed link(s) |
|---|---|---|---|
| 70 | UniProtKB | 3134887 | |
| 70 | OGlycoBase | 89096927 | |
| 70 | N-GlycoSiteAtlas | 24190977 | |
| 70 | dbPTM | 3134887 | |
| 89 | UniProtKB | 3134887 | |
| 89 | OGlycoBase | 89096927 | |
| 89 | dbPTM | 3134887 | |
| 218 | OGlycoBase | 89096927 | |
| 218 | UniProtKB | 3134887 | |
| 218 | dbPTM | 3264879 | |
| 224 | UniProtKB | 3134887 | |
| 224 | OGlycoBase | 89096927 | |
| 224 | dbPTM | 3264879 | |
| 229 | UniProtKB | 3134887 | |
| 229 | OGlycoBase | 89096927 | |
| 229 | dbPTM | 3264879 | |
| 236 | dbPTM | 3264879 | |
| 236 | OGlycoBase | 89096927 | |
| 237 | dbPTM | 3264879 | |
| 237 | OGlycoBase | 89096927 | |
| 237 | UniProtKB | 3134887 |
Family and domain data
| Database | Domain/Family name |
|---|---|
| InterPro | IL-2_rcpt_alpha |
| InterPro | Sushi/SCR/CCP_sf |
| InterPro | Sushi_SCR_CCP_dom |
| Pfam | Sushi |