PolarProtDb

Gene name

Igfbp7 (Mac25,PSF)

Experiment(s)

For this entry:

IBP7_HUMAN (Igfbp7)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Touzelet O,Broadbent L,Armstrong SD,Aljabr W,Cloutman-Green E,Power UF,Hiscox JA (2020) The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins., Mol Cell Proteomics, 19, 793-807. [PubMed] [DOI]
Evidence level	Large-scale proteomics
Organ	Lung
Cell	Airway epithel cells
Notes	Only mock-transfected cells were considered

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	282	Extracellular

Phosphorylation

Position	Resource
117	23115190
122	23115184
137	34371955
142	34371958
201	35479857
239	50831262
253	23115187

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
31	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
39	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
125	O-GlycoProteomDB
126	O-GlycoProteomDB
149	O-GlycoProteomDB
171	UniProtKB		8939990
171	dbPTM		8939990
171	N-GlycoSiteAtlas		24495048
188	UniCarbKB	$WURCS=2.0/2,2,1/[uxxxxh_2*NCC/3=O][uxxxxh]/1-2/a?\|b?}-{a?\|b?$	30459171
206	PolarProtDb		29296958
206	O-GlycoProteomDB
206	PhosphoSitePlus
206	dbPTM		55831157
220	PhosphoSitePlus
220	O-GlycoProteomDB
220	PolarProtDb		29296958
220	dbPTM		55824677
230	PhosphoSitePlus
230	O-GlycoProteomDB
230	dbPTM		55824683
230	PolarProtDb		29296958
236	PhosphoSitePlus
236	dbPTM		55826111
236	O-GlycoProteomDB
239	O-GlycoProteomDB
253	O-GlycoProteomDB
258	O-GlycoProteomDB
260	O-GlycoProteomDB
264	PhosphoSitePlus
264	PolarProtDb		29296958
264	PolarProtDb		29296958
264	dbPTM		55824287
264	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Growth_fac_rcpt_cys_sf
InterPro	Ig-like_dom
InterPro	Ig-like_dom_sf
InterPro	Ig-like_fold
InterPro	Ig_I-set
InterPro	Ig_sub
InterPro	IGFBP-like
InterPro	IGFBP_rP_mac25
InterPro	Kazal_dom
InterPro	Kazal_dom_sf
Pfam	I-set
Pfam	IGFBP
Pfam	Kazal_2