PolarProtDb

Gene name

IGFBP4 (Igfbp-4,IBP4)

Experiment(s)

For this entry:

IBP4_HUMAN (IGFBP4)

Species	Homo sapiens
Localization	Basolateral plasma membrane
Reference	Remacle-Bonnet M,Garrouste F,el Atiq F,Marvaldi J,Pommier G (1995) Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells., J Clin Invest, 96, 192-200. [PubMed] [DOI]
Evidence level	Selective medium analysis
Organ	Large intestine
Cell	HT29-D4 cells (enterocytes)
Notes	Endogenous protein was detected

For ortholog entries:

Alignment and sequence features

Wheel: zoom in/out; drag: scroll left/right. Sequences and features are drawn in three lines. Bottom line: topology (red bar: cytoplasmic region; yellow bar: transmembrane region; transmembrane re-entrant loop; blue bar: extracellular region; black bar: signal peptide). Middle line: amino acid sequence (grey bar or one letter code). Top line: post translational modifications (Y: N-glycosylation site; Y: O-glycosylation site;P: phosphorylation site), intrinsically disordered regions (light green bar: IDR) and short linear motifs (light steel blue bar: ELM region).

CCTOP topology prediction

Start	End	Localisation
1	258	Extracellular

Phosphorylation

Position	Resource
255	56653663

Glycosylation

Position	Site resource	Glycan resource	PubMed link(s)
125	dbPTM		1709161
125	N-GlycoSiteAtlas		23586699
150	PolarProtDb	$WURCS=2.0/3,3,2/[AUd21122h_5NCC/3=O][uxxxxh_2NCC/3=O][uxxxxh]/1-2-3/a?\|b?\|c?}-{a?\|b?\|c?_a?\|b?\|c?}-{a?\|b?\|c?$	27695962
173	PhosphoSitePlus
173	dbPTM		55829379
173	O-GlycoProteomDB
188	O-GlycoProteomDB
190	O-GlycoProteomDB

Family and domain data

Database	Domain/Family name
InterPro	Growth_fac_rcpt_cys_sf
InterPro	IGFBP-4
InterPro	IGFBP-like
InterPro	IGFBP_1-6_chordata
InterPro	Insulin_GF-bd_Cys-rich_CS
InterPro	Thyroglobulin_1
InterPro	Thyroglobulin_1_sf
Pfam	IGFBP
Pfam	Thyroglobulin_1

Interactions

With (links to EBI)	#Exp	PubMed links
IGF2_HUMAN	4	unassigned1913

Protein can be found in apical membrane, Protein can be found in basal membrane, Protein can be found both membranes, Localisation is unknown.